SYNTHESIS OF DOPAMINE AND OCTOPAMINE IN THE CRUSTACEAN STOMATOGASTRIC NERVOUS-SYSTEM
SYNTHESIS OF DOPAMINE AND OCTOPAMINE IN THE CRUSTACEAN STOMATOGASTRIC NERVOUS-SYSTEM
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DOI：
10.1016/0006-8993(79)90198-7
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发表时间：
1979-01-01
期刊：
影响因子：
2.9
通讯作者：
HOOPER, NK
中科院分区：
文献类型：
--
作者：
BARKER, DL;KUSHNER, PD;HOOPER, NK
多刺龙虾（断沟龙虾）的胃神经系在体外可由外源性[³H]酪氨酸合成多巴胺和章鱼胺。每种胺在该系统内9个分别分析的区域中呈现特定的分布。未观察到其他儿茶酚胺的合成。在神经、神经节以及已确定的连合神经节细胞体中发现了[³H]多巴胺，这些部位已证实有儿茶酚胺组织荧光。生物合成和组织化学数据表明，多巴胺能细胞从连合神经节沿激活幽门运动网络的纤维所走的相同路径向胃神经节神经纤维网发送轴突。如在体外所观察到的，多巴胺在体内介导幽门系统激活这一假设得到了支持。[³H]章鱼胺主要在连合神经节和胃神经节中积累，它可能调节神经元活动，但在胃神经系内未确定章鱼胺能细胞和释放位点。
The spiny lobster [Panulirus interruptus] stomatogastric nervous system synthesizes dopamine and octopamine in vitro from exogenous [3H]tyrosine. Each amine accumulates with a specific distribution among 9 separately analyzed regions within the system. Synthesis of other catecholamines was not observed. [3H]Dopamine is found in nerves, ganglia and identified commissural ganglion cell bodies in which catecholamine histofluorescence was demonstrated. The biosynthetic and histochemical data indicate that dopaminergic cells send axons from the commissural ganglia to the stomatogastric ganglion neuropile along the same pathway followed by fibers that activate the pyloric motor network. The hypothesis that dopamine mediates activation of the pyloric system in vivo, as observed in vitro, is supported. [3H]Octopamine accumulates primarily in the commissural and stomatogastric ganglia, where it may modulate neuronal activity, but octopaminergic cells and release sites within the stomatogastric system were not identified.