Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior
Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior
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DOI：
10.1101/lm.729408
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发表时间：
2008-03-01
影响因子：
2
通讯作者：
Meck, Warren H.
中科院分区：
文献类型：
--
作者：
Cheng, Ruey-Kuang;MacDonald, Christopher J.;Meck, Warren H.
母亲饮食中的胆碱对后代的大脑和行为有持久的影响。为了进一步描述早期营养状况的影响，我们研究了产前补充胆碱对成年雄性和雌性大鼠的时间、情绪和记忆表现的影响。在胚胎第 12-17 天 (ED) 期间给予足够胆碱 (CON: 1.1 g/kg) 或补充胆碱 (SUP: 5.0 g/kg) 的大鼠采用低速率差异强化 (DRL) 计划进行训练，该计划逐渐过渡到 5、10、18、36 和 72 秒标准时间。我们观察到，SUP 女性比 CON 女性发出更多的强化反应，这比两组男性都更有效。此外，与两组 CON 大鼠相比，SUP 雄性和 SUP 雌性大鼠的爆发响应（响应延迟 < 2 秒）有所减少。此外，尽管突发反应水平降低，但由于在过渡到新标准后维持先前的 DRL 标准，SUP 雄性在 DRL 标准之前做出了更多非强化反应。总之，产前补充胆碱的持久效果表现在，SUP 男性的沮丧 DRL 反应减少，时间记忆持续存在，而 SUP 女性的时间探索和反应效率增强。
Choline availability in the maternal diet has a lasting effect on brain and behavior of the offspring. To further delineate the impact of early nutritional status, we examined effects of prenatal-choline supplementation on timing, emotion, and memory performance of adult male and female rats. Rats that were given sufficient choline (CON: 1.1 g/kg) or supplemental choline (SUP: 5.0 g/kg) during embryonic days (ED) 12-17 were trained with a differential reinforcement of low-rate (DRL) schedule that was gradually transitioned through 5-, 10-, 18-, 36-, and 72-sec criterion times. We observed that SUP-females emitted more reinforced responses than CON-females, which were more efficient than both groups of males. In addition, SUP-males and SUP-females exhibited a reduction in burst responding (response latencies < 2 sec) compared with both groups of CON rats. Furthermore, despite a reduced level of burst responding, the SUP-males made more nonreinforced responses prior to the DRL criterion as a result of maintaining the previous DRL criterion following transition to a new criterion. In summary, long-lasting effects of prenatal-choline supplementation were exhibited by reduced frustrative DRL responding in conjunction with the persistence of temporal memory in SUP-males and enhanced temporal exploration and response efficiency in SUP-females.