The actions of retinoids on cellular growth correlate with their actions on gap junctional communication.
The actions of retinoids on cellular growth correlate with their actions on gap junctional communication.
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DOI：
10.1083/jcb.108.3.1053
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发表时间：
1989-03
期刊：
影响因子：
--
通讯作者：
Loewenstein WR
中科院分区：
文献类型：
--
作者：
Mehta PP;Bertram JS;Loewenstein WR
视黄酸（一种可能的形态原）、其生物前体视黄醇和某些视黄醇的合成衍生物深刻地改变了10t1 /2和3T3细胞及其转化对应细胞的连接细胞间通讯和生长（饱和密度）。这些变化是相互关联的：随着稳态连接渗透率的增加，生长减少，随着渗透率的下降，生长增加。在正常细胞中，视黄酸和视黄醇在非细胞毒性浓度下对通讯发挥完全不同的稳态作用：视黄酸在10(-10)-10(-9)M时抑制通讯，在10(-9)-10(-7)M时增强通讯，而视黄醇仅在10(-8)-10(-6)M时增强通讯。在v-mos转化的细胞中，这种增强完全没有。但无论类视黄醛或细胞类型，所有的生长反应都表现出对连接通透性的基本相同的依赖性。如果间隙连接的细胞间通道通过细胞群传播生长调节信号，这是预期的行为。
Retinoic acid (a possible morphogen), its biological precursor retinol, and certain synthetic derivatives of retinol profoundly change junctional intercellular communication and growth (saturation density) in 10T 1/2 and 3T3 cells and in their transformed counterparts. The changes correlate: growth decreases as the steady-state junctional permeability rises, and growth increases as that permeability falls. Retinoic acid and retinol exert quite different steady-state actions on communication at noncytotoxic concentrations in the normal cells: retinoic acid inhibits communication at 10(-10)-10(-9) M and enhances at 10(-9)-10(-7) M, whereas retinol only enhances (10(-8)-10(-6) M). In v-mos-transformed cells the enhancement is altogether lacking. But regardless of the retinoid or cell type, all growth responses show essentially the same dependence on junctional permeability. This is the expected behavior if the cell-to-cell channels of gap junctions disseminate growth-regulating signals through cell populations.