Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
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DOI：
10.1016/j.jaci.2008.01.072
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发表时间：
2008-05-01
影响因子：
14.2
通讯作者：
Till, Stephen J.
中科院分区：
文献类型：
--
作者：
Francis, James N.;James, Louisa K.;Till, Stephen J.
背景：草花粉免疫疗法是季节性变应性鼻炎的一种有效治疗方法，为研究过敏原特异性免疫耐受的诱导和维持提供了机会。目的：我们调查了免疫治疗1年期间临床反应性、调节性细胞因子产生和过敏原抗体应答之间的关系。方法：18例重症季节性变应性鼻炎患者随机双盲接受明胶吸附草花粉疫苗(Alutard SQ)活性或安慰剂注射。受试者接受了对皮内过敏原的早期和晚期皮肤反应的重复测试，以及对草花粉变应原的细胞反应的测试。结果：草花粉免疫治疗能有效降低患者的总症状积分(P
Background: Grass pollen immunotherapy is an effective treatment for seasonal allergic rhinitis that provides the opportunity to study the induction and maintenance of allergen-specific immune tolerance.Objectives: We investigated the relationship between clinical responsiveness, regulatory cytokine production, and antibody responses to allergen during 1 year of immunotherapy.Methods: Eighteen subjects with severe seasonal allergic rhinitis were randomized double-blind to receive active or placebo injections of an alum-adsorbed grass pollen vaccine (Alutard SQ). Subjects underwent repeated testing of early- and late-phase skin responses to intradermal allergen, and cellular responses to grass pollen allergen were tested. Sera were tested for allergen-specific IgG4, IgA, and inhibitory activity in biologic assays of IgE responses.Results: Grass pollen immunotherapy was effective in reducing overall symptom scores (P