Role of DNA polyrnerase IV in Escherichia coli SOS mutator activity

Role of DNA polyrnerase IV in Escherichia coli SOS mutator activity
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DOI:
10.1128/jb.01088-06
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发表时间:
2006-11-01
影响因子:
3.2
通讯作者:
Fijalkowska, Iwona J.
Fijalkowska, Iwona J.
中科院分区:
生物学3区
文献类型:
--
作者:
Kuban, Wojciech;Banach-Orlowska, Magdalena;Fijalkowska, Iwona J.

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SOS调控子在大肠杆菌recA730菌株中的组成性表达导致依赖于DNA聚合酶V (umuDC基因产物)的突变表型(SOS突变子)。在这里,我们表明这种作用的很大一部分也需要DNA聚合酶IV (dinB基因产物)。
Constitutive expression of the SOS regulon in Escherichia coli recA730 strains leads to a mutator phenotype (SOS mutator) that is dependent on DNA polymerase V (umuDC gene product). Here we show that a significant fraction of this effect also requires DNA polymerase IV (dinB gene product).