Hepatocyte nuclear factor-4α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells
Hepatocyte nuclear factor-4α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells
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DOI：
10.1042/bj20021382
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发表时间：
2003-01-01
影响因子：
4.1
通讯作者：
O'Brien, RM
中科院分区：
文献类型：
--
作者：
Boustead, JN;Stadelmaier, BT;O'Brien, RM
最近有研究表明，肝细胞中腺病毒介导的过氧化物酶体增殖物激活受体γ共激活物-1 α (PGC-1 α)的表达可刺激葡萄糖-6-磷酸酶催化亚基（G6Pase）基因的表达。融合基因、凝胶阻滞和染色质免疫沉淀试验的结合表明，在H4IIE细胞中，PGC-1alpha通过G6Pase启动子的一个进化保守区域介导这种刺激，该区域结合肝细胞核因子-4alpha。
It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4alpha.