Wnt/β-catenin signaling:: new (and old) players and new insights
Wnt/β-catenin signaling:: new (and old) players and new insights
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DOI：
10.1016/j.ceb.2008.01.009
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发表时间：
2008-04-01
影响因子：
7.5
通讯作者：
He, Xi
中科院分区：
文献类型：
--
作者：
Huang, He;He, Xi
Wnt/β-连环蛋白信号传导在胚胎发生和包括癌症在内的人类疾病中具有核心作用。Writ途径的中心方案是通过防止其磷酸化依赖性降解来稳定转录共激活因子β-连环蛋白。对这一关键调控途径的理解已经取得了重大进展，包括促进β-连环蛋白磷酸化降解的蛋白质复合物，以及细胞外Writ配体与细胞表面受体结合以抑制β-连环蛋白磷酸化降解的机制。在这里，我们回顾了这两个领域的一些最新发现，并强调了一些关键的问题，仍然有待解决。
Wnt/beta-catenin signaling has central roles in embryogenesis and human diseases including cancer. A central scheme of the Writ pathway is to stabilize the transcription coactivator beta-catenin by preventing its phosphorylation-dependent degradation. Significant progress has been made toward the understanding of this crucial regulatory pathway, including the protein complex that promotes beta-catenin phosphorylation-degradation, and the mechanism by which the extracellular Writ ligand engages cell surface receptors to inhibit beta-catenin phosphorylation-degradation. Here we review some recent discoveries in these two areas, and highlight some crucial questions that remain to be resolved.