The influence of risk and monetary payment on the research participation decision making process
The influence of risk and monetary payment on the research participation decision making process
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DOI：
10.1136/jme.2002.001594
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发表时间：
2004-06-01
影响因子：
4.1
通讯作者：
Thacker, P. G.
中科院分区：
文献类型：
--
作者：
Bentley, J. P.;Thacker, P. G.
目的：为了确定风险和支付对受试者的参与意愿的影响，并研究支付如何影响受试者的潜在行为和风险evaluations.Methods：A 3（风险水平）× 3（货币支付水平），受试者之间，完全随机析因设计。就读于美国五所药学院之一的学生阅读了一项假设研究的招募通知和知情同意书，并完成了一份问卷调查。风险水平是使用假设的生物医学研究项目的招募通知和知情同意书来操纵的。支付水平是使用Dickert和Grady评估的支付模式作为指导来确定的。五个因变量进行了评估，在问卷调查：愿意参与，愿意参与没有支付，倾向忽视告诉有关限制活动，倾向忽视告诉有关负面影响，和risk rating.Results：金钱支付有积极影响受访者的意愿，参与研究，无论风险水平。然而，更高的金钱支付似乎并没有使受访者对研究的风险视而不见。报酬对受访者隐瞒受限制活动信息的潜在行为有一定影响。然而，支付似乎并没有显着影响受访者的倾向忽视告诉researchers about negative effects.Conclusions：货币支付似乎做他们打算做的事情：使受试者更愿意参与研究。在本研究中，无法证实关于支付费用使受试者对风险保持盲态的担忧。然而，研究结果确实引发了其他担忧-特别是付款可能会削弱研究结果的完整性。未来的研究对于就研究对象的支付做出合理的决定至关重要。
Objectives: To determine the effects of risk and payment on subjects' willingness to participate, and to examine how payment influences subjects' potential behaviours and risk evaluations.Methods: A 3 ( level of risk) x 3 ( level of monetary payment), between subjects, completely randomised factorial design was used. Students enrolled at one of five US pharmacy schools read a recruitment notice and informed consent form for a hypothetical study, and completed a questionnaire. Risk level was manipulated using recruitment notices and informed consent documents from hypothetical biomedical research projects. Payment levels were determined using the payment models evaluated by Dickert and Grady as a guide. Five dependent variables were assessed in the questionnaire: willingness to participate, willingness to participate with no payment, propensity to neglect to tell about restricted activities, propensity to neglect to tell about negative effects, and risk rating.Results: Monetary payment had positive effects on respondents' willingness to participate in research, regardless of the level of risk. However, higher monetary payments did not appear to blind respondents to the risks of a study. Payment had some influence on respondents' potential behaviours regarding concealing information about restricted activities. However, payment did not appear to have a significant effect on respondents' propensity to neglect to tell researchers about negative effects.Conclusions: Monetary payments appear to do what they are intended to do: make subjects more willing to participate in research. Concerns about payments blinding subjects to risks could not be substantiated in the present study. However, the findings do raise other concerns - notably the potential for payments to diminish the integrity of a study's findings. Future research is critical to make sound decisions about the payment of research subjects.