NERVE GROWTH-FACTOR IN THE SYNOVIAL-FLUID OF PATIENTS WITH CHRONIC ARTHRITIS
NERVE GROWTH-FACTOR IN THE SYNOVIAL-FLUID OF PATIENTS WITH CHRONIC ARTHRITIS
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DOI：
10.1002/art.1780350315
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发表时间：
1992-03-01
影响因子：
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通讯作者：
LEVIMONTALCINI, R
中科院分区：
文献类型：
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作者：
ALOE, L;TUVERI, MA;LEVIMONTALCINI, R
细胞因子在炎症过程中调节神经生长因子（NGF）的合成。 由于细胞因子也参与了自身免疫性风湿性疾病的炎症过程，我们检测了类风湿性关节炎或其他类型慢性关节炎患者的NGF水平。 NGF存在于慢性关节炎患者的滑液和滑膜中，但在对照液中检测不到。 结论：NGF可能参与关节炎的发病机制。
Cytokines regulate nerve growth factor (NGF) synthesis during inflammatory processes. Since cytokines are also involved in the inflammatory processes of autoimmune rheumatic diseases, we examined levels of NGF in patients with rheumatoid or other types of chronic arthritis. NGF was present in the synovial fluid and synovium of patients with chronic arthritis, but was undetectable in control fluids. We conclude that NGF might be involved in the pathogenesis of arthritis.