BLIMP-I: trigger for differentiation of myeloid lineage
BLIMP-I: trigger for differentiation of myeloid lineage
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DOI：
10.1038/77861
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发表时间：
2000-08-01
影响因子：
30.5
通讯作者：
Calame, K
中科院分区：
文献类型：
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作者：
Chang, DH;Angelin-Duclos, C;Calame, K
B淋巴细胞诱导成熟蛋白-1(BLIMP-1或PRDI-BF1)是当骨髓祖细胞在巨噬细胞集落刺激因子(M-CSF)刺激下分化时诱导的，存在于外周血单核细胞和粒细胞中。BLIMP-1在U937和HL-60细胞分化为巨噬细胞或粒细胞的过程中也被诱导。U937和HL-60巨噬细胞分化过程中BLIMP-1mRNA的诱导呈双相模式。过表达blimp-1足以启动U937细胞的巨噬细胞分化，而阻断内源性blimp-1则抑制分化。在U937细胞中，依赖blimp-1的转录抑制的一个靶点是c-myc，这为细胞分裂的停止提供了解释。因此，BLIMP-1在两种不同的造血系中是终末分化的关键调节因子：髓系细胞和B淋巴细胞。
B lymphocyte-induced maturation protein-1 (BLIMP-1 or PRDI-BF1) is induced when bone marrow-derived progenitors differentiate in response to macrophage-colony stimulating factor (M-CSF) and is present in peripheral blood monocytes and granulocytes. BLIMP-1 is also induced during differentiation of U937 and HL-60 cells into macrophages or granulocytes. Induction of BLIMP-1 mRNA during macrophage differentiation of U937 and HL-60 shows a biphasic pattern. Overexpression of BLIMP-1 is sufficient to initiate macrophage differentiation of U937 cells whereas blocking endogenous BLIMP-1 inhibits differentiation. One target of BLIMP-1-dependent transcriptional repression in U937 cells is c-myc, providing an explanation for cessation of cell division. Thus BLIMP-1 is a key regulator of terminal differentiation in two separate hematopoietic lineages: myeloid cells and B lymphocytes.