RELATIONSHIP OF INTERMEDIATE AND LOW-DENSITY-LIPOPROTEIN SUBSPECIES TO RISK OF CORONARY-ARTERY DISEASE
RELATIONSHIP OF INTERMEDIATE AND LOW-DENSITY-LIPOPROTEIN SUBSPECIES TO RISK OF CORONARY-ARTERY DISEASE
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DOI：
10.1016/0002-8703(87)90636-3
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发表时间：
1987-02-01
影响因子：
4.8
通讯作者：
KRAUSS, RM
中科院分区：
文献类型：
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作者：
KRAUSS, RM
最近的研究表明，人血浆低密度脂蛋白（LDL）的异质性部分是由于两种中密度脂蛋白（IDL）亚种产生不同的LDL产物。在动脉粥样硬化性血脂异常（家族性高胆固醇血症和3型高脂蛋白血症）患者的血浆中发现了两种富含胆固醇的IDL物种，其物理性质与胆固醇喂养猴子血浆中的主要物种相似。家族性合并高脂血症患者血浆中IDL水平升高，LDL亚类（LDL- iiia）更小、密度更大，可能是较小的IDL亚种的代谢产物。NHLBI II型冠状动脉干预研究的结果支持小IDL-LDL途径与冠状动脉疾病之间的联系，2年内这些物种水平的变化与疾病进展有关。此外，治疗后IDL水平的降低与高密度脂蛋白胆固醇的升高相关。因此，IDL水平的变化可能通过直接影响和间接影响LDL颗粒数以及可能的高密度脂蛋白代谢影响冠状动脉疾病的风险。
Recent studies have shown that heterogeneity of human plasma low-density lipoproteins (LDL) is, in part, the result of production of different LDL products from two subspecies of intermediate-density lipoproteins (IDL). Cholesterol-enriched forms of both IDL species are found in plasma of patients with atherogenic dyslipidemias (familial hypercholesterolemia and type 3 hyperlipoproteinemia) and have physical properties similar to the major species in plasma of cholesterol-fed monkeys. Patients with familial combined hyperlipidemia have been shown to have increased plasma levels of IDL and of a smaller, denser LDL subclass (LDL-IIIA) that appears to be a metabolic product of the smaller IDL subspecies. Results from the NHLBI Type II Coronary intervention study have supported a link between the small IDL-LDL pathway and coronary disease, In that 2-year changes in levels of these species were associated with disease progression. Furthermore, therapeutic reductions in IDL levels were correlated with increases in high-density lipoprotein cholesterol. Thus variation in IDL levels might influence coronary disease risk by both a direct effect and indirectly by affecting LDL particle number and possibly high-density lipoprotein metabolism.