CURRENT CONCEPTS IN CANCER - HYPOXIC SENSITIZERS - IMPLICATIONS FOR RADIATION-THERAPY
CURRENT CONCEPTS IN CANCER - HYPOXIC SENSITIZERS - IMPLICATIONS FOR RADIATION-THERAPY
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DOI：
10.1056/nejm197912273012606
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
CHAPMAN, JD
中科院分区：
文献类型：
--
作者：
CHAPMAN, JD
人体细胞的增殖能力可以被电离辐射破坏，在有氧的条件下，辐射的杀伤率比在缺氧条件下高2.5至3倍。由于实体瘤通常有坏死区，因此可能含有缺氧但存活的细胞，这种放射生物学效应可能对癌症治疗有影响。放射治疗后存活下来的耐放射性肿瘤细胞会重新氧化，导致疾病复发。最近对2803例接受放射治疗的宫颈癌患者的分析表明，血红蛋白水平<100 μ g/ml的患者，其血红蛋白水平可能会降低。
THE proliferative capacity of human cells can be destroyed by ionizing radiation, and the rate of killing by radiation is 2.5 to three times higher in the presence of oxygen than under hypoxic conditions. Since solid tumors often have zones of necrosis and consequently are likely to contain hypoxic yet viable cells, this radiobiologic effect may have implications for cancer therapy. Radioresistant tumor cells that survive treatment can become reoxygenated and lead to a recurrence of the disease.A recent analysis of 2803 patients with carcinoma of the cervix treated with radiation therapy indicated that those with hemoglobin levels of . . .