Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum.
Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum.
复制标题
DOI：
10.1016/j.bpsc.2016.07.004
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Koenigs M
中科院分区：
文献类型：
--
作者：
Korponay C;Pujara M;Deming P;Philippi C;Decety J;Kosson DS;Kiehl KA;Koenigs M
精神病是一种以冷酷和冲动的反社会行为为特征的精神健康障碍，与暴力犯罪、药物滥用和累犯的高发生率有关。最近的研究表明，纹状体可能是这种疾病的神经生物学基础的关键组成部分，尽管结构上的发现是混合的，精神变态中纹状体的功能连接还没有得到充分的检查。我们利用大样本成年男性监狱囚犯(N=124)，对精神病患者的纹状体体积和功能连通性进行了多模式神经成像研究。我们在纹状体亚核进行了体积分析，随后在体积与精神疾病严重程度相关的区域评估了静息状态功能连接。PCL-R总分和因子2评分(指示精神变态的冲动/反社会特征)与纹状体亚核体积较大和纹状体焦点区域体积增加有关，特别是在双侧伏隔核和壳核。此外，在许多纹状体区域，体积与因子2得分呈正相关，精神疾病的严重程度也与与其他脑区的异常功能连接有关，包括背外侧前额叶皮质、腹侧中脑和纹状体的其他区域。这些结果与年龄、种族、智商、物质使用史或颅内体积无关。这些发现将精神变态的冲动/反社会维度与纹状体亚核扩大和纹状体与其他大脑区域之间异常的功能连接联系起来。此外，体积和功能连接发现的共同定位表明，这些神经异常可能与病理生理相关。
Psychopathy is a mental health disorder characterized by callous and impulsive antisocial behavior, and is associated with a high incidence of violent crime, substance abuse, and recidivism. Recent studies suggest that the striatum may be a key component of the neurobiological basis for the disorder, though structural findings have been mixed and functional connectivity of the striatum in psychopathy has yet to be fully examined. We performed a multimodal neuroimaging study of striatum volume and functional connectivity in psychopathy, using a large sample of adult male prison inmates (N=124). We conducted volumetric analyses in striatal subnuclei, and subsequently assessed resting-state functional connectivity in areas where volume was related to psychopathy severity. Total PCL-R and Factor 2 scores (which index the impulsive/antisocial traits of psychopathy) were associated with larger striatal subnuclei volumes and increased volume in focal areas throughout the striatum, particularly in the nucleus accumbens and putamen bilaterally. Furthermore, at many of the striatal areas where volume was positively associated with Factor 2 scores, psychopathy severity was also associated with abnormal functional connectivity with other brain regions, including dorsolateral prefrontal cortex, ventral midbrain and other areas of the striatum. The results were not attributable to age, race, IQ, substance use history, or intracranial volume. These findings associate the impulsive/antisocial dimension of psychopathy with enlarged striatal subnuclei and aberrant functional connectivity between the striatum and other brain regions. Furthermore, the co-localization of volumetric and functional connectivity findings suggests that these neural abnormalities may be pathophysiologically linked.