Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling.
Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling.
复制标题
通过肠内分泌细胞先天免疫信号传导肠道稳态的微生物控制。
DOI：
10.1016/j.tim.2019.09.005
复制
发表时间：
2020
影响因子：
15.9
通讯作者：
Jugder,Bat-Erdene
中科院分区：
文献类型：
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作者：
Watnick,PaulaI;Jugder,Bat-Erdene
共生微生物群落，称为肠道微生物群，存在于动物胃肠道内，在维持宿主代谢稳态和抵抗病原体入侵方面发挥着作用。肠内分泌细胞在肠上皮中相对较少，已经进化到能够感知这些共生微生物并做出反应。具体来说，它们表达 G 蛋白偶联受体和功能性先天免疫信号通路，分别识别微生物代谢产物和微生物相关分子模式。在这里，我们回顾了来自果蝇的最新证据，即微生物信号会招募肠内分泌先天免疫系统的抗菌、机械和代谢分支，并认为这种反应不仅可能在维持宿主代谢稳态中发挥作用，而且可能在肠道抵抗细菌、病毒和寄生病原体入侵方面发挥作用。
A community of commensal microbes, known as the intestinal microbiota, resides within the gastrointestinal tract of animals and plays a role in maintenance of host metabolic homeostasis and resistance to pathogen invasion. Enteroendocrine cells, which are relatively rare in the intestinal epithelium, have evolved to sense and respond to these commensal microbes. Specifically, they express G-protein-coupled receptors and functional innate immune signaling pathways that recognize products of microbial metabolism and microbe-associated molecular patterns, respectively. Here we review recent evidence fromDrosophila melanogasterthat microbial cues recruit antimicrobial, mechanical, and metabolic branches of the enteroendocrine innate immune system and argue that this response may play a role not only in maintaining host metabolic homeostasis but also in intestinal resistance to invasion by bacterial, viral, and parasitic pathogens.