A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
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DOI：
10.1055/s-0038-1632990
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发表时间：
2006-01-01
影响因子：
1.3
通讯作者：
McIlwraith, C. W.
中科院分区：
文献类型：
--
作者：
Frisbie, D. D.;Cross, M. W.;McIlwraith, C. W.
在关节软骨的临床前研究中，使用了非钙化和钙化软骨的组织学测量，以及股骨滑车和股骨内侧髁上五个位置的软骨下骨板的厚度，并与人类膝关节的厚度进行了比较。获得了6个人类膝盖的尸体标本，以及6个马、6个山羊、6个狗、6个绵羊和6个兔子的膝关节（相当于人类膝盖的动物）。标本取自滑车外侧脊、滑车内侧脊和股骨内侧髁。组织病理学处理后，测量非钙化和钙化软骨层的厚度，以及软骨下板的厚度。5个部位关节软骨平均厚度：人2.2 ~ 2.5 mm，兔0.3 mm，羊0.4 ~ 0.5 mm，狗0.6 ~ 1.3 mm，山羊0.7 ~ 1.5 mm，马1.5 ~ 2 mm。马提供了最接近人类的关节软骨厚度，这种近似被认为与软骨愈合的临床前研究有关。
Histological measurements of the thickness of non-calcified and calcified cartilage, as well as the subchondral bone plate in five locations on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee. Cadaver specimens were obtained of six human knees, as well as six equine, six goat, six dog, six sheep and six rabbit stifle joints (the animal equivalent of the human knee). Specimens were taken from the lateral trochlear ridge, medial trochlear ridge and medial femoral condyle. After histopathological processing, the thickness of non-calcified and calcified cartilage layers, as well as the subchondral bone plate, was measured. Average articular cartilage thickness over five locations were 2.2-2.5 mm for human, 0.3 mm for rabbit, 0.4-0.5 mm for sheep, 0.6-1.3 mm for dog, 0.7-1.5 mm for goat and 1.5-2 mm for horse. The horse provides the closest approximation to humans in terms of articular cartilage thickness, and this approximation is considered relevant in pre-clinical studies of cartilage healing.