Irradiation of paranasal sinus tumors, a delineation and dose comparison study
Irradiation of paranasal sinus tumors, a delineation and dose comparison study
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DOI：
10.1016/s0360-3016(01)01751-5
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发表时间：
2002-01-01
影响因子：
7
通讯作者：
Lebesque, JV
中科院分区：
文献类型：
--
作者：
Rasch, C;Eisbruch, A;Lebesque, JV
目的：为了确定观察者的变化和治疗计划的变化对照射时，鼻窦canceres.Patients和方法的目标和正常结构的剂量的影响：9例鼻窦肿瘤进行了减积手术和随后的放射治疗。来自两个不同机构的两名观察员描绘了择期和加强体积的临床靶体积（CTV）。这些体积在三维空间中扩展，边缘为5 mm。在这两个机构，设计了一个三维适形治疗计划，46戈伊的选择体积，加上20戈伊的增强目标体积。划定的体积和治疗计划进行了compared.Results：选择CTVs的机构之间的平均体积比为0.9（标准误= 0.05）。差异主要位于鼻腔底部和靶区额缘。增强CTVs的差异很大;平均体积比为2.6（标准误差= 0.58）。CTV扩大后，计划靶体积（PTV）和视交叉之间的平均距离相差0.5 cm。PTV与视交叉距离越小的病例PTV剂量不足越多。对于机构A，这种效果不太明显（1体积%/ cm）比机构B（10体积%/ cm）治疗计划，这些计划不太符合要求。当为机构B的PTV设计治疗计划时。机构A收到的PTV的23体积%
Purpose: To determine the influence of observer variation and treatment planner variation on the dose delivered to the target and normal structures when irradiating paranasal sinus carcinomas.Patients and Methods: Nine patients with paranasal sinus tumors underwent debulking surgery and subsequent radiation therapy. Two observers from two different institutions delineated the clinical target volumes (CTVs) for the elective and the boost volumes. These volumes were expanded in three dimensions with a 5-mm margin. At both institutions, a three-dimensional conformal treatment plan of 46 Gy to the elective volumes, plus 20 Gy to the boost target volumes, was designed. The delineated volumes and treatment plans were compared.Results: The mean volume ratio between institutions of the elective CTVs was 0.9 (standard error = 0.05). The differences were located mainly at the bottom of the nasal cavity and at the frontal border of the target areas. The differences in boost CTVs were large; the mean volume ratio was 2.6 (standard error = 0.58). After expansion of the CTV, the mean distance between the planning target volume (PTV) and the chiasm differed by 0.5 cm between the two institutions. Cases with smaller distances between the PTV and the chiasm had more underdosage to the PTV. This effect was less pronounced for institution A (1 vol.%/cm) than for institution B (10 vol.%/cm) treatment plans, which were less conformal. When the treatment plan was designed for the PTV of institution B. 23 volume % of the PTV of institution A received