The functional role of Langerhans cells.
The functional role of Langerhans cells.
复制标题
朗格汉斯细胞的功能作用。
DOI：
10.1111/1523-1747.ep12543548
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
E. Shevach
中科院分区：
文献类型：
--
作者：
G. Stingl;S. Katz;I. Green;E. Shevach
Langerhans cells represent a subpopulation of mammalian epidermal cells. The recent findings that these cells are the only epidermal cells which express Fc-IgG receptors, C3 receptors and Ia antigens support the early suggestion that they are related to cells from the monocyte-macrophage-histiocyte series. In this report, evidence is presented that epidermal Langerhans cell can replace Ia-bearing macrophages in their capacity to induce antigen-specific and allogeneic T cell activation. The possible clinical implications of these findings are discussed with regard to the role of Langerhans cells as sensitizing factors in contact hypersensitivity and skin graft rejection.
