Distribution of a family of Haemophilus influenzae genes containing CCAA nucleotide repeating units
Distribution of a family of Haemophilus influenzae genes containing CCAA nucleotide repeating units
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DOI：
10.1111/j.1574-6968.1999.tb13583.x
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发表时间：
1999-05-15
影响因子：
2.1
通讯作者：
Stull, TL
中科院分区：
文献类型：
--
作者：
Morton, DJ;Stull, TL
已在流感嗜血杆菌中鉴定出直接在编码前导肽的序列之后含有CCAA核苷酸重复单元长度的基因家族。CCAA重复序列的长度范围为6至43，所有鉴定的基因编码的蛋白质或预测的蛋白质与细菌铁或血红素相关的外膜蛋白具有显着的同源性。我们以前已经表明，这些基因产物中的两个，HgpA和HgpB，结合血红蛋白和血红蛋白-触珠蛋白复合物。进行了研究，以确定物种分布的五个确定的基因和CCAA重复。我们发现，CCAA基序和血红蛋白和血红蛋白-触珠蛋白结合的结构基因广泛分布于H。流感病毒株。(C)1999年由Elsevier Science B. V.出版，版权所有。
A family of genes containing lengths of CCAA nucleotide repeating units directly following the sequence encoding the leader peptide has been identified in Haemophilus influenzae. The length of the CCAA repeats ranges from 6 to 43 and all of the identified genes encode proteins or predicted proteins with a significant homology to bacterial iron- or heme-related outer membrane proteins. We have previously shown that two of these gene products, HgpA and HgpB, bind hemoglobin and the hemoglobin-haptoglobin complex. Studies were performed to define the species distribution of the five identified genes and the CCAA repeats. We show that both the CCAA motif and the structural genes for hemoglobin and hemoglobin-haptoglobin binding are widely distributed among H. influenzae strains. (C) 1999 Published by Elsevier Science B.V. All rights reserved.