Long-Chain Peer Referral of Men Who Have Sex With Men: A Novel Approach to Establish and Maintain a Cohort to Measure HIV Incidence, Nanjing, China
Long-Chain Peer Referral of Men Who Have Sex With Men: A Novel Approach to Establish and Maintain a Cohort to Measure HIV Incidence, Nanjing, China
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DOI：
10.1097/qai.0b013e318239c947
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发表时间：
2012-02-01
影响因子：
3.6
通讯作者：
McFarland, Willi
中科院分区：
文献类型：
--
作者：
Yan, Hongjing;Yang, Haitao;McFarland, Willi
背景：我国男男性行为人群（MSM）中HIV感染率较高。需要进行纵向研究来衡量艾滋病毒的发病率，确定感染的原因，并测试预防干预措施。我们描述了2种新的方法来招募和维持一个队列的男男性接触者，专注于他们的能力，以建立一个多样化的样本，提高保留率，其对HIV incidence.Methods的影响：采用基于响应驱动抽样的方法，我们构建了2个平行队列测量HIV发病率超过2年，通过6个月的随访。第二阶段为开放队列，招募MSM完成follow-up.Results：397例HIV阴性MSM入组初始队列，460例入组开放队列。在招募浪潮中，队列的组成是稳定的。在初始参与者中，保留率分别为72.0%、68.8%、49.9%和44.8%。开放队列的保留率较低。MSM保留在这两个阶段的风险低于那些失去后续行动。艾滋病病毒的发病率为3.36每100人年，并没有不同的招聘methods.Conclusions：我们的方法有效地招募MSM到纵向研究，从最初的招聘样本多样性的适度改善。我们认为有多种手段来改善多样性和后续行动，利用征聘人员之间的网络纽带，并通过二级奖励措施来协助转诊和留用。同时，南京市男男性行为人群中HIV感染率较高，需要制定干预措施并进行纵向随机对照试验。
Background: HIV prevalence is high among men who have sex with men (MSM) in China. Longitudinal studies are needed to measure HIV incidence, determine causes of acquisition, and test prevention interventions. We described 2 novel methods to enroll and maintain a cohort of MSM, focusing on their abilities to establish a diverse sample, improve retention, and their impact on HIV incidence.Methods: Employing methods based on respondent-driving sampling, we constructed 2 parallel cohorts measuring HIV incidence over 2 years through 6-month follow-up visits. An initial cohort was constructed using long-chain peer referral from the community; a second phase comprised open cohort peer referral recruitment from MSM completing follow-up.Results: Three-hundred ninety-seven HIV-negative MSM were enrolled in the initial cohort; 460 were recruited in the open cohort phase. Across recruitment waves, the composition of the cohort was stable. Among initial participants, retention was 72.0%, 68.8%, 49.9%, and 44.8%. Retention was lower in the open cohort. MSM retained in both phases were less risky than those lost to follow-up. HIV incidence was 3.36 per 100 person-years and did not differ by recruitment method.Conclusions: Our approach efficiently recruited MSM into longitudinal studies with modest improvement in sample diversity from initial recruits. We perceive multiple means to improve diversity and follow-up capitalizing on the network bonds between recruits and through secondary incentives for assistance with referral and retention. Meanwhile, HIV incidence is high among MSM in Nanjing, and interventions need to be developed and tested in longitudinal randomized controlled trials.