The extent of diversity of anti‐hapten antibodies in inbred mice: anti‐NIP (4‐hydroxy‐5‐iodo‐3‐nitro‐phenacetyl) antibodies in CBA/H mice
The extent of diversity of anti‐hapten antibodies in inbred mice: anti‐NIP (4‐hydroxy‐5‐iodo‐3‐nitro‐phenacetyl) antibodies in CBA/H mice
复制标题
近交小鼠中抗半抗原抗体的多样性程度：CBA/H 小鼠中的抗 NIP（4-羟基-5-碘-3-硝基-苯乙酰基）抗体
DOI：
10.1002/eji.1830030306
复制
发表时间：
1973
影响因子：
5.4
通讯作者：
A. Williamson
中科院分区：
文献类型：
--
作者：
H. Kreth;A. Williamson
估计了近交系CBA/H小鼠可以产生的不同抗NIP（4-羟基-5-碘-3-硝基-苯乙酰基）分子的数量。已使用脾细胞转移，并确定受体小鼠血清中存在的抗体的等电谱。来自不同供体小鼠的单克隆抗体谱组之间的比较给出了单个谱的重复频率。该频率允许统计估计（见附录）CBA/H小鼠中可能引发的不同抗NIP分子的最小数量。此池的最可能值为8000，其中池超过3000的概率为98%，池小于30000的概率为95%。
The number of different anti‐NIP (4‐hydroxy‐5‐iodo‐3‐nitro‐phenacetyl) molecules which inbred CBA/H mice can make was estimated. Spleen cell transfer has been used and the isoelectric spectra of antibodies present in the sera of recipient mice determined. Comparison between the sets of monoclonal antibody spectra deriving from different donor mice gave a repeat frequency for individual spectra. This frequency permitted a statistical estimate (see Addendum) of the minimum number of different anti‐NIP molecules potentially capable of being elicited in CBA/H mice. The most likely value of this pool is 8000 with 98 % probability that pool exceeds 3000 and 95 % probability that pool is less than 30 000.