Effects of autosomal inversions on meiotic exchange in distal and proximal regions of the X chromosome in a natural population of Drosophila melanogaster.
Effects of autosomal inversions on meiotic exchange in distal and proximal regions of the X chromosome in a natural population of Drosophila melanogaster.
复制标题
常染色体倒位对果蝇自然群体 X 染色体远端和近端区域减数分裂交换的影响。
DOI：
10.1017/s0016672300032080
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Hughes,KA
中科院分区：
文献类型：
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作者：
Sniegowski,PD;Pringle,A;Hughes,KA
我们研究了(2L)t和(3R)P中自然发生的着丝粒旁倒位对果蝇X染色体两个区域减数分裂重组的影响。以前的作者曾提出，由于杂合性常染色体倒位的染色体间效应，一些自然群体中X染色体顶端的重组率可能比实验室测得的值高得多。这一建议的动机是观察到，转座元素在X染色体顶端并不像最近的研究预测的那样常见，该研究将减数分裂交换减少与元素丰度增加联系在一起。以自然群体等基因主染色体为背景，研究了(2L)t和(3R)P杂合对X染色体顶端和碱基重组的影响。这两种倒置都显著增加了碱基的重组速度；两种倒置都不影响末端的重组。结果表明，研究人群中倒位的存在并不会提高X染色体顶端的交叉率。讨论了这些结果与转座元素丰度与重组率之间的关系。
We have investigated the interchromosomal effect of the naturally-occurring paracentric inversions In(2L)t and In(3R)P on meiotic recombination in two regions of the X chromosome in Drosophila melanogaster. Previous authors have suggested that the rate of recombination at the tip of the X chromosome may be substantially higher in some natural populations than values measured in the laboratory, due to the interchromosomal effect of heterozygous autosomal inversions. This suggestion was motivated by observations that transposable elements are not as common at the tip of the X chromosome as predicted by recent research relating reduced meiotic exchange to increased element abundance in D. melanogaster. We examined the effects of heterozygous In(2L)t and In(3R)P on recombination at both the tip and base of the X chromosome on a background of isogenic major chromosomes from a natural population. Both inversions substantially increased the rate of recombination at the base; neither one affected recombination at the tip. The results suggest that the presence of inversions in the study population does not elevate rates of crossing over at the tip of the X chromosome. The relevance of these results to ideas relating transposable element abundance to recombination rates is discussed.