Accelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture.
Accelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture.
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DOI：
10.1002/smll.202307928
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发表时间：
2023-10
期刊：
影响因子：
13.3
通讯作者：
Zaman Ataie;S. Horchler;Arian Jaberi;Srinivas V Koduru;Jessica C El-Mallah;Mingjie Sun;Sina Kheirabadi;Alexander Kedzierski;Aneesh Risbud;Angelo Roncalli Alves E Silva;D. Ravnic;Amir Sheikhi
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文献类型：
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作者：
Zaman Ataie;S. Horchler;Arian Jaberi;Srinivas V Koduru;Jessica C El-Mallah;Mingjie Sun;Sina Kheirabadi;Alexander Kedzierski;Aneesh Risbud;Angelo Roncalli Alves E Silva;D. Ravnic;Amir Sheikhi
块状水凝胶支架在重建手术中很常见。它们通过为血运重建提供基础，可以分阶段修复软组织损失。不幸的是，它们受到缓慢且随机的血管形成的限制，这可能表现为治疗失败或修复欠佳。在生物材料中快速诱导图案化血管化对于当前的临床治疗范例和再生工程平台的规模化具有深远的转化意义。为了解决这一长期存在的挑战，共同开发了一种新颖的显微外科方法和颗粒水凝胶支架（GHS）技术，以加速和模拟微血管网络的形成。在外科微穿刺 (MP) 中，使用微针对目标受体血管进行穿孔，以加速细胞外渗和血管生成。通过将 MP 与具有精确定制的空隙空间结构的相邻 GHS 相结合，可以快速引导通过密度、直径、长度和毛细血管间距离评估的微血管图案形成。这项工作为微血管工程、推进重建手术和再生医学开辟了新的转化机会。
Bulk hydrogel scaffolds are common in reconstructive surgery. They allow for the staged repair of soft tissue loss by providing a base for revascularization. Unfortunately, they are limited by both slow and random vascularization, which may manifest as treatment failure or suboptimal repair. Rapidly inducing patterned vascularization within biomaterials has profound translational implications for current clinical treatment paradigms and the scaleup of regenerative engineering platforms. To address this long-standing challenge, a novel microsurgical approach and granular hydrogel scaffold (GHS) technology are co-developed to hasten and pattern microvascular network formation. In surgical micropuncture (MP), targeted recipient blood vessels are perforated using a microneedle to accelerate cell extravasation and angiogenic outgrowth. By combining MP with an adjacent GHS with precisely tailored void space architecture, microvascular pattern formation as assessed by density, diameter, length, and intercapillary distance is rapidly guided. This work opens new translational opportunities for microvascular engineering, advancing reconstructive surgery, and regenerative medicine.