Systems biology and the discovery of diagnostic biomarkers.
Systems biology and the discovery of diagnostic biomarkers.
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系统生物学和诊断生物标志物的发现。
DOI：
10.3233/dma-2010-0697
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Galas D
中科院分区：
文献类型：
--
作者：
Wang K;Lee I;Carlson G;Hood L;Galas D
系统生物学是一种科学方法，它将生物学视为一门信息科学，研究整个生物系统及其与环境的相互作用。由于此处描述的原因，这种方法在寻找疾病的信息诊断生物标志物方面具有特殊的能力，因为它侧重于识别和理解疾病扰动分子网络的根本原因和关键。在这篇综述中，我们描述了一些利用系统生物学来解决复杂疾病（朊病毒病和药物引起的肝损伤）的最新进展，并以这些为例来说明理解网络结构和动态的重要性。通过体外实验扰动和建模获得的网络动力学知识使我们能够确定网络的状态，识别分子相关性，并得出新的疾病治疗方法来逆转病理或通过操纵网络状态来防止其进展到更严重的状态。这种包括诊断和治疗在内的通用方法正被称为系统医学。
Systems biology is an approach to the science that views biology as an information science, studies biological systems as a whole and their interactions with the environment. This approach, for the reasons described here, has particular power in the search for informative diagnostic biomarkers of diseases because it focuses on the fundamental causes and keys on the identification and understanding of disease- perturbed molecular networks. In this review, we describe some recent developments that have used systems biology to address complex diseases – prion disease and drug induced liver injury- and use these as examples to illustrate the importance of understanding network structure and dynamics. The knowledge of network dynamics through in vitro experimental perturbation and modeling allows us to determine the state of the networks, to identify molecular correlates, and to derive new disease treatment approaches to reverse the pathology or prevent its progress into a more severe state through the manipulation of network states. This general approach, including diagnostics and therapeutics, is becoming known as systems medicine.