Toxicity of zearalenone on the intestines of pregnant sows and their offspring and alleviation with modified halloysite nanotubes
Toxicity of zearalenone on the intestines of pregnant sows and their offspring and alleviation with modified halloysite nanotubes
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DOI：
10.1002/jsfa.8517
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发表时间：
2018-01-30
影响因子：
4.1
通讯作者：
Chen, Zhihui
中科院分区：
文献类型：
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作者：
Liu, Min;Zhu, Dandan;Chen, Zhihui
本研究的目的是研究母体暴露于玉米赤霉烯酮（ZEN）对妊娠母猪和出生后第1、21和188天（PD）后代肠道的影响。18头妊娠母猪（每处理6头）从妊娠第35天（GD）至第70天（GD）分别饲喂对照日粮（ZEN，0.03mg kg（-1））、ZEN日粮（ZEN，2.77mg kg（-1））和ZEN+1%改性埃洛石纳米管（MHNT）日粮（ZEN，2.76mg kg（-1））。试验结束后，分别于GD 70和PD 1、PD 21、PD 188日处死各组母猪各3头，观察仔猪肠道的变化。结果表明，ZEN可引起妊娠母猪和PD 1、PD 21仔猪的氧化应激、炎症反应、空肠结构的改变以及盲肠空肠细菌数量的变化。在PD 188中，细菌数量也发生了变化。补充MHNTs可以减少肠道中ZEN的含量，并在很大程度上逆转ZEN对妊娠母猪及其后代肠道的影响。结论本研究结果表明，MHNTs处理有利于母猪肠道中ZEN的吸收。(c)2017年化学工业协会
BACKGROUNDThe objective of this study was to examine the effects of maternal exposure to zearalenone (ZEN) on the intestines of pregnant sows and offspring on postnatal days (PD) 1, 21 and 188. Eighteen pregnant sows (six per treatment) were fed a control diet (ZEN, 0.03mg kg(-1)), ZEN diet (ZEN, 2.77mg kg(-1)) and ZEN+1% modified halloysite nanotube (MHNT) diet (ZEN, 2.76mg kg(-1)) respectively from gestation days (GD) 35 to 70. At the end of the experiment, three sows of each group on GD70 and the offspring on PD1, PD21 and PD188 were killed to analyze the changes of intestines.RESULTSThe results showed that ZEN caused oxidative stress, an inflammatory response, changes in the structure of jejunum and alterations of the bacterial numbers in cecal digesta in pregnant sows and PD1 and PD21 piglets. On PD188, bacterial numbers were also altered. MHNTs supplementation reduced the amount of ZEN in the intestine and reversed to a large extent the effects induced by ZEN on the intestines of pregnant sows and offspring.CONCLUSIONThe results obtained from this study indicated that MHNTs treatment was beneficial for the adsorption of ZEN in the intestine of sows. (c) 2017 Society of Chemical Industry