How does the histone code work?
How does the histone code work?
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DOI：
10.1139/o05-137
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发表时间：
2005-08-01
影响因子：
2.9
通讯作者：
Wolberger, C
中科院分区：
文献类型：
--
作者：
Cosgrove, MS;Wolberger, C
组蛋白翻译后修饰的模式与调节DNA访问的不同染色体状态相关，导致了组蛋白密码假说。然而，目前尚不清楚柔性组蛋白尾巴的修饰如何导致核小体动力学的变化，从而导致染色质结构的变化。最近的发现，就像柔性的组蛋白尾巴一样，核小体核心颗粒的结构化球状结构域也被广泛修饰，这为组蛋白密码假说增加了一个新的令人兴奋的维度，并呼吁重新检查当前染色质结构的表观遗传调控模型。在这里，我们回顾了这些发现和其他最近的研究，这些研究表明核小体核心颗粒的结构球状结构域在调节染色质动力学方面起着关键作用。
Patterns of histone post-translational modifications correlate with distinct chromosomal states that regulate access to DNA, leading to the histone-code hypothesis. However, it is not clear how modification of flexible histone tails leads to changes in nucleosome dynamics and, thus, chromatin structure. The recent discovery that, like the flexible histone tails, the structured globular domain of the nucleosome core particle is also extensively modified adds a new and exciting dimension to the histone-code hypothesis, and calls for the re-examination of current models for the epigenetic regulation of chromatin structure. Here, we review these findings and other recent studies that suggest the structured globular domain of the nucleosome core particle plays a key role regulating chromatin dynamics.