Inflammatory markers and the metabolic syndrome - Insights from therapeutic interventions
Inflammatory markers and the metabolic syndrome - Insights from therapeutic interventions
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DOI：
10.1016/j.jacc.2005.06.082
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发表时间：
2005-12-06
影响因子：
24
通讯作者：
Quon, MJ
中科院分区：
文献类型：
--
作者：
Koh, KK;Han, SH;Quon, MJ
血管炎症可能是心血管疾病和代谢综合征之间的重要致病环节。炎症可以通过多种方法减少，包括饮食，运动，心血管药物和胰岛素增敏剂。重要的是，这些不同的措施通过不同的机制改善血管功能并减少炎症。因此，包括生活方式改变和不同类别的多种药物在内的联合治疗可能会产生额外的有益结果。我们回顾了在动脉粥样硬化、冠心病和高血压的胰岛素抵抗状态（包括糖尿病、肥胖和代谢综合征）中联合治疗减轻炎症、改善内皮功能障碍和降低胰岛素抵抗的可能机制。
Inflammation in the vasculature might be an important pathogenic link between cardiovascular diseases and the metabolic syndrome. Inflammation can be reduced by a variety of approaches including diet, exercise, cardiovascular drugs, and insulin sensitizers. Importantly, these different measures improve vascular function and reduce inflammation by distinct mechanisms. Therefore, combination therapy including lifestyle modifications and multiple drugs from separate classes might produce additive beneficial outcomes. We review plausible mechanisms for effects of combination therapy to reduce inflammation, improve endothelial dysfunction, and decrease insulin resistance in atherosclerosis, coronary heart disease, and hypertension in the context of insulin-resistant states including diabetes, obesity, and the metabolic syndrome.