High risk of HIV-related mortality is associated with selenium deficiency
High risk of HIV-related mortality is associated with selenium deficiency
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DOI：
10.1097/00042560-199708150-00007
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发表时间：
1997-08-15
期刊：
影响因子：
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通讯作者：
Page, JB
中科院分区：
文献类型：
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作者：
Baum, MK;ShorPosner, G;Page, JB
为了确定特定免疫和营养因素对HIV-1疾病患者存活率的独立影响，我们考虑了CD 4细胞计数、抗逆转录病毒治疗、血浆维生素A、E、B-6和B-12水平以及矿物质硒和锌与HIV相关死亡率的相对风险。在佛罗里达州迈阿密的125名H1 V-1血清阳性药物使用男性和女性中，每隔6个月评价一次已知影响免疫功能的免疫参数和营养素，为期3.5年。在为期3.5年的纵向研究中，共有21名HIV-1感染者死于HIV相关原因。亚临床营养不良（即，前白蛋白水平过低，相对危险度[RR] = 4.01，p < 0.007），维生素A缺乏（RR = 3.23，p 0.03），维生素B-12缺乏（RR = 8.33，p < 0.009），缺锌（RR = 2.29.1，p < 0.04），硒缺乏（RR = 19.9，p < 0.0001），而不是齐多夫定治疗，均与HIV-1相关死亡率相关，与CD 4细胞计数无关
To determine the independent contribution of specific immunologic and nutritional factors on survival in HIV-1 disease, CD4 cell count, antiretroviral treatment, plasma levels of vitamins A, E, B-6, and B-12 and minerals selenium and zinc were considered in relation to relative risk for HIV-related mortality. Immune parameters and nutrients known to affect immune function were evaluated at 6-month intervals in 125 H1V-1-seropositive drug-using men and women in Miami, FL, over 3.5 years. A total of 21 of the HIV-1-infected participants died of HIV-related causes during the 3.5-year longitudinal study. Subclinical malnutrition (i.e., overly low levels of prealbumin, relative risk [RR] = 4.01, p < 0.007), deficiency of vitamin A (RR = 3.23, p 0.03), vitamin B-12 deficiency (RR = 8.33, p < 0.009), zinc deficiency (RR = 2.29.1, p < 0.04), and selenium deficiency (RR = 19.9, p < 0.0001) over time, but not zidovudine treatment, were shown to each be associated with HIV-1-related mortality independent of CD4 cell counts