THE PLATELET INTERACTIVITY PHENOTYPE OF STREPTOCOCCUS-SANGUIS INFLUENCES THE COURSE OF EXPERIMENTAL ENDOCARDITIS
THE PLATELET INTERACTIVITY PHENOTYPE OF STREPTOCOCCUS-SANGUIS INFLUENCES THE COURSE OF EXPERIMENTAL ENDOCARDITIS
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DOI：
10.1128/iai.60.11.4809-4818.1992
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发表时间：
1992-11-01
影响因子：
3.1
通讯作者：
MEYER, MW
中科院分区：
文献类型：
--
作者：
HERZBERG, MC;MACFARLANE, GD;MEYER, MW
在家兔实验性心内膜炎中，一种诱导家兔血小板体外聚集（Agg+表型）的血链球菌菌株被假设为比Agg-菌株毒力更强的病原体。植入左心室导管，然后静脉内接种Agg+或Agg-菌株。主动脉半月瓣上形成赘生物，但不受导管植入持续时间的影响。赘生物因血小板聚集而扩大，其质量随心内膜炎持续时间直接增加。接种Agg+菌株持续引起心内膜炎，伴明显更大的赘生物，临床病程更严重（包括发热发作、血液学变化和心肌缺血的体征）、主要器官中更多的肉眼病变和比接种Agg-菌株、生理盐水，或用抗其血小板聚集相关蛋白（PAA.P; II类）的单特异性兔免疫球蛋白G或Fab片段预处理的Agg+菌株。在实验性心内膜炎中，PAAP以Agg+ S.血吸虫是重要的毒力因子。
A strain of Streptococcus sanguis that induced rabbit platelets to aggregate in vitro (Agg+ phenotype) was hypothesized to be a more virulent pathogen than an Agg- strain in experimental endocarditis in rabbits. A left ventricular catheter was implanted, and then an Agg+ or Agg- strain was inoculated intravenously. Vegetations formed on the aortic semilunar valves but were unaffected by the duration of implantation of the catheter. Vegetations enlarged by accumulating platelets and their mass increased directly with the duration of endocarditis. Inoculation of the Agg+ strain consistently caused endocarditis with significantly larger vegetations, a more severe clinical course (including febrile episodes, hematological changes, and signs of myocardial ischemia), more gross lesions in major organs, and greater mortality than inoculation with the Agg- strain, saline, or the Agg+ strain pretreated with monospecific rabbit immunoglobulin G or Fab fragments against its platelet aggregation-associated protein (PAA.P; class II). In experimental endocarditis, PAAP expressed by Agg+ S. sanguis appeared to be an important virulence factor.