QUANTITATIVE-ANALYSIS OF ENDONEURIAL T-CELLS IN HUMAN SURAL NERVE BIOPSIES
QUANTITATIVE-ANALYSIS OF ENDONEURIAL T-CELLS IN HUMAN SURAL NERVE BIOPSIES
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DOI：
10.1016/0165-5728(90)90082-x
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发表时间：
1990-02-01
影响因子：
3.3
通讯作者：
MCARTHUR, JC
中科院分区：
文献类型：
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作者：
CORNBLATH, DR;GRIFFIN, DE;MCARTHUR, JC
我们用免疫细胞化学方法对42例周围神经病患者的腓肠神经活检组织进行鉴定，以确定单个核细胞，确定淋巴细胞是否在各种神经病变中存在，并确定淋巴细胞的亚型。76%的神经活检组织中有免疫染色细胞。CD3+细胞(T淋巴细胞)密度最大(cell/mm2)。在血液和脑脊液中也测量了CD4/CD8T细胞比率的患者中，所有三个隔室的CD4/CD8T细胞比率都是相似的。这些发现表明，T淋巴细胞经常存在于各种神经病患者的神经中，并提出了吸引T淋巴细胞进入神经的因素，这可能在发病机制中起重要作用。
We used immunocytochemical methods on sural nerve biopsies from 42 patients with peripheral neuropathy to identify mononuclear cells, determine whether lymphocytic infiltration occurs in a variety of neuropathies, and identify the subtypes of lymphocytes. Immunostained cells were present in 76% of nerve biopsies. CD3+ cells (T lymphocytes) were greatest in density (cells/mm2). In patients whose CD4:CD8 T cell ratio was measured also in blood and cerebrospinal fluid, the CD4:CD8 T cell ratio was similar in all three compartments. These findings suggest that T lymphocytes are frequently present in nerves obtained from patients with various types of neuropathies and raise questions about factors that attract T lymphocytes into nerve that may be important in pathogenesis.