Choosing important health outcomes for comparative effectiveness research: 6th annual update to a systematic review of core outcome sets for research.
Choosing important health outcomes for comparative effectiveness research: 6th annual update to a systematic review of core outcome sets for research.
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DOI：
10.1371/journal.pone.0244878
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Williamson PR
中科院分区：
文献类型：
--
作者：
Gargon E;Gorst SL;Matvienko-Sikar K;Williamson PR
对用于研究的核心成果集(COS)进行系统审查的年度更新确保彗星数据库是最新的。这项研究的目的是：(I)确定2019年出版或编入索引的COS，并描述这些研究中使用的方法；(Ii)调查已发表的COS发展研究是否包括儿童作为参与者，以及采用了哪些方法促进他们的参与；iii)更新先前的练习，以确定与最沉重的全球疾病和伤害相关的COS。对Medline和Scope进行了搜索，以确定在2019年1月至2019年12月期间发表或编入索引的研究。自动筛选方法被用来按相关性顺序对引文进行排名；排在优先顺序中排名前25%的人被筛选出资格。对照每个核心成果集--发展标准(COS-STAD)对COS进行评估。对COMET数据库进行了搜索，以确定与造成疾病负担的25个主要原因有关的COS。这次更新包括了33项研究，描述了37个COS的发展情况。这些研究已被添加到彗星数据库中，该数据库现在包含370项已发表的(1981-2019年)COS临床研究研究。在本次更新的33项研究中，有6项(18%)被认为达到了COS发展的所有最低标准(范围=4至12个标准，中位数=9个标准)。在迄今发表的370项COS研究中，82项COS是针对儿科健康状况制定的，儿童有资格参与其中的68/82项研究。在这68项COS研究中，有11项(16%)将儿童作为发展过程的参与者，最常见的是通过参与德尔福调查。为全球疾病负担的22/25个主要原因确定了相关的COS。在为研究和常规实践而开发的COS中，已经有了明显的增长，并且患者参与者的包容性一直很高。为儿科条件制定的COS需要进一步纳入儿童、父母和其他成年人的观点，并采用适合于此目的的研究方法。COS开发者应该将此次更新中发现的差距作为COS开发的优先事项。
An annual update to a systematic review of core outcome sets (COS) for research ensures that the COMET database is up-to-date. The aims of this study were to: (i) identify COS that were published or indexed in 2019 and to describe the methodological approaches used in these studies; (ii) investigate whether children have been included as participants in published COS development studies, and which methods have been used to facilitate their participation; iii) update a previous exercise to identify COS relevant to the most burdensome global diseases and injuries. MEDLINE and SCOPUS were searched to identify studies published or indexed between (and inclusive of) January 2019 and December 2019. Automated screening methods were used to rank the citations in order of relevance; the top 25% in ranked priority order were screened for eligibility. COS were assessed against each of the Core Outcome Set-STAndards for Development (COS-STAD). A search of the COMET database was undertaken to identify COS relevant to the 25 leading causes of disease burden. Thirty-three studies, describing the development of 37 COS, were included in this update. These studies have been added to the COMET database, which now contains 370 published (1981–2019) COS studies for clinical research. Six (18%) of the 33 studies in this update were deemed to have met all of the minimum standards for COS development (range = 4 to 12 criteria, median = 9 criteria). Of the 370 COS studies published to date, 82 COS have been developed for paediatric health conditions and children would have been eligible to participate in 68/82 of these studies. Eleven of these 68 (16%) COS studies have included children as participants within the development process, most commonly through participation in Delphi surveys. Relevant COS were identified for 22/25 leading causes of global disease burden. There has been a demonstrated increase in COS developed for both research and routine practice, and consistently high inclusion of patient participants. COS developed for paediatric conditions need to further incorporate the perspectives of children, alongside parents and other adults, and adopt research methods fit for this purpose. COS developers should consider the gaps identified in this update as priorities for COS development.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
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影响因子：
3.7
作者：
Gargon E;Gurung B;Medley N;Altman DG;Blazeby JM;Clarke M;Williamson PR
通讯作者：
Williamson PR
DOI：
10.1038/s41572-020-0159-z
发表时间：
2020-03-12
期刊：
Nature reviews. Disease primers
影响因子：
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作者：
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DOI：
10.1093/incorrectjnlcode/baz109
发表时间：
2019-11-07
影响因子：
5.8
作者：
Norman, Christopher R.;Gargon, Elizabeth;Williamson, Paula R.
通讯作者：
Williamson, Paula R.
影响因子：
15.8
作者：
Kirkham JJ;Davis K;Altman DG;Blazeby JM;Clarke M;Tunis S;Williamson PR
通讯作者：
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