A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands
A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands
复制标题
通过选择无甲基化岛分离出囊性纤维化基因座的候选者
作者：
X. Estivill;M. Farrall;P. Scambler;G. Bell;K. Hawley;N. Lench;G. Bates;H. Kruyer;P. Frederick;P. Stanier;E. Watson;R. Williamson;B. Wainwright
具有 HTF 岛特征的靠近囊性纤维化基因座的基因组序列已被选择性克隆和表征。该序列两侧的两个标记在整个哺乳动物进化过程中都是保守的，显示出比任何现有标记所发现的更大的不平衡。大多数囊性纤维化病例都是由单一突变事件引起的。该序列被表达，并且是囊性纤维化基因的候选者。
A genomic sequence close to the cystic fibrosis locus with the characteristics of an HTF island has been selectively cloned and characterized. Two markers flanking this sequence, which is conserved throughout mammalian evolution, show a very much greater disequilibrium than that found with any existing marker. A single mutational event accounts for most cases of cystic fibrosis. The sequence is expressed, and is a candidate for the cystic fibrosis gene.
囊性纤维化与两个紧密相连的 DNA 标记的联系：一项合作研究的联合报告。
影响因子：
9.8
作者：
Beaudet,A;Bowcock,A;Buchwald,M;Cavalli-Sforza,L;Farrall,M;King,MC;Klinger,K;Lalouel,JM;Lathrop,G;Naylor,S
通讯作者：
Naylor,S