High Density Lipoproteins and Diabetes.
High Density Lipoproteins and Diabetes.
复制标题
高密度脂蛋白和糖尿病。
作者：
Cochran BJ;Ong KL;Manandhar B;Rye KA
流行病学研究已经确定，高血浆高密度脂蛋白胆固醇（HDL-C）水平与心血管风险降低有关。然而，最近增加HDL-C水平的干预措施的随机临床试验未能建立这种关系的因果关系。这导致HDL研究工作转向开发改善HDL心脏保护功能的策略，而不是简单地增加HDL-C水平。这些努力也导致了与心血管疾病无关的新HDL功能的发现。最近发现的HDL的功能之一是其有效的抗糖尿病特性。本文就高密度脂蛋白的抗糖尿病作用及其研究进展作一综述。鉴于全球所有形式的糖尿病都在以惊人的速度增长，明确需要确定和开发新的方法，以补充现有的治疗方法，减少疾病进展并逆转已建立的疾病。探索HDL及其组成脂质和载脂蛋白在这一领域的潜在作用显然是必要的。这篇综述强调了尚未研究的重点领域和利用HDL抗糖尿病功能的潜在策略。
Epidemiological studies have established that a high plasma high density lipoprotein cholesterol (HDL-C) level is associated with reduced cardiovascular risk. However, recent randomised clinical trials of interventions that increase HDL-C levels have failed to establish a causal basis for this relationship. This has led to a shift in HDL research efforts towards developing strategies that improve the cardioprotective functions of HDLs, rather than simply increasing HDL-C levels. These efforts are also leading to the discovery of novel HDL functions that are unrelated to cardiovascular disease. One of the most recently identified functions of HDLs is their potent antidiabetic properties. The antidiabetic functions of HDLs, and recent key advances in this area are the subject of this review. Given that all forms of diabetes are increasing at an alarming rate globally, there is a clear unmet need to identify and develop new approaches that will complement existing therapies and reduce disease progression as well as reverse established disease. Exploration of a potential role for HDLs and their constituent lipids and apolipoproteins in this area is clearly warranted. This review highlights focus areas that have yet to be investigated and potential strategies for exploiting the antidiabetic functions of HDLs.
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DOI：
10.1161/atvbaha.116.307385
发表时间：
2016-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Apro J;Tietge UJ;Dikkers A;Parini P;Angelin B;Rudling M
通讯作者：
Rudling M
影响因子：
7.7
作者：
Cochran BJ;Hou L;Manavalan AP;Moore BM;Tabet F;Sultana A;Cuesta Torres L;Tang S;Shrestha S;Senanayake P;Patel M;Ryder WJ;Bongers A;Maraninchi M;Wasinger VC;Westerterp M;Tall AR;Barter PJ;Rye KA
通讯作者：
Rye KA
影响因子：
6.5
作者：
Asztalos, Bela F.;Schaefer, Ernst J.;Calabresi, Laura
通讯作者：
Calabresi, Laura
影响因子：
158.5
作者：
Barter, Philip J.;Caulfield, Mark;Brewer, Bryan
通讯作者：
Brewer, Bryan
影响因子：
16.2
作者：
Brahimaj, Adela;Ligthart, Symen;Dehghan, Abbas
通讯作者：
Dehghan, Abbas