In preeclampsia, the placenta grows slowly along its minor axis
In preeclampsia, the placenta grows slowly along its minor axis
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DOI：
10.1387/ijdb.082833ek
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发表时间：
2010-01-01
影响因子：
0.7
通讯作者：
Barker, David J. P.
中科院分区：
文献类型：
--
作者：
Kajantie, Eero;Thornburg, Kent L.;Barker, David J. P.
出生时胎盘表面积较小与后代患高血压的风险增加有关。先兆子痫与着床受损和后代血压升高有关。我们假设先兆子痫与胎盘表面积较小有关。我们研究了 1934-44 年间赫尔辛基大学中央医院 6410 例分娩的胎盘大小。其中 284 例妊娠并发先兆子痫。 1855人并发高血压，无蛋白尿。胎盘表面的面积是根据常规记录的两个直径来估计的，一个是最大直径，另一个是与其成直角的较小直径。与血压正常妊娠相比，并发子痫前期妊娠的胎盘表面积减少，表面更加椭圆形。然而，厚度增加了。当两个直径一起分析时，先兆子痫与最大直径的长度无关，但与较短的较小直径密切相关（p
A small placental surface area at birth is associated with an increased risk of hypertension in the offspring in later life. Preeclampsia is associated with impaired implantation and with increased blood pressure in the offspring. We hypothesized that preeclampsia would be associated with a small placental surface area. We studied placental size in 6410 deliveries at the Helsinki University Central Hospital during 1934-44. 284 of the pregnancies were complicated by preeclampsia. 1855 were complicated by hypertension without proteinuria. The area of the placental surface was estimated from two diameters that were routinely recorded, a maximal diameter and a lesser one at right angles to it. Compared to normotensive pregnancies, the placentas from pregnancies complicated by preeclampsia had a reduced surface area and the surface was more oval. The thickness, however, was increased. When the two diameters were analyzed together, preeclampsia was not associated with the length of the maximal diameter, but was strongly associated with a short lesser diameter (p