Nicotinic mechanisms of memory:: effects of acute local DHβE and MLA infusions in the basolateral amygdala
Nicotinic mechanisms of memory:: effects of acute local DHβE and MLA infusions in the basolateral amygdala
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DOI：
10.1016/s0926-6410(02)00209-4
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发表时间：
2003-03-01
期刊：
影响因子：
--
通讯作者：
Levin, ED
中科院分区：
文献类型：
--
作者：
Addy, NA;Nakijama, A;Levin, ED
Nicotine has been shown to improve working memory. The neural mechanisms underlying this effect are still being determined. The ventral hippocampus is critical for nicotinic effects on memory. Local ventral hippocampal infusions of either the nicotinic alpha7 nicotinic receptor antagonist methyllycaconitine (MLA) or the alpha4beta2 nicotinic receptor antagonist dihydro-beta-erythroidine (DHbetaE) caused working memory impairments, but no additive effects were seen. Other areas, such as the amygdala, also likely play important roles in nicotinic effects on memory. Amygdalar lesions cause memory impairment and there is a dense concentration of nicotinic receptors in the basolateral amygdala. The current study used local basolateral amygdalar infusions of the nicotinic antagonists MLA and DHbetaE to determine the involvement of alpha7 and alpha4beta2 nicotinic receptors in spatial working and reference memory. Rats (n=8) were trained in the 16-arm radial maze and were implanted with bilateral infusion cannulae into the basolateral amygdala. Acute infusions of MLA (6.75 mug/side, P
