Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid-Conjugated PDA Hydrogel through Dual-Light Triggered ROS and Membrane Permeability
Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid-Conjugated PDA Hydrogel through Dual-Light Triggered ROS and Membrane Permeability
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通过双光触发 ROS 和膜渗透性对碳量子点/ZnO 装饰的可注射叶酸共轭 PDA 水凝胶进行快速高效的杀菌
DOI：
10.1002/smll.201900322
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发表时间：
2019
期刊：
影响因子：
13.3
通讯作者：
Wu Shuilin
中科院分区：
文献类型：
--
作者：
Xiang Yiming;Mao Congyang;Liu Xiangmei;Cui Zhenduo;Jing Doudou;Yang Xianjin;Liang Yanqin;Li Zhaoyang;Zhu Shengli;Zheng Yufeng;Yeung Kelvin Wai Kwok;Zheng Dong;Wang Xianbao;Wu Shuilin
细菌感染是生物医学领域面临的最大挑战之一，它对人类健康造成了巨大的危害。本工作通过过渡金属离子(TMI)交联的多巴胺(DA)和叶酸(FA)的快速组装，合成了一种可注射的水凝胶，称为DFT-水凝胶。FA分子中的两个羧基和多巴胺(PDA)中的儿茶酚都很容易螯合锌离子形成金属-配体配位，从而使这种可注射水凝胶与伤口的形状相匹配。此外，包覆在碳量子点修饰的氧化锌纳米颗粒(NPs)的水凝胶中的PDA能够在660 nm和808 nm的光照下快速产生活性氧物种(ROS)和加热，使这种杂化水凝胶对金黄色葡萄球菌(典型的金黄色葡萄球菌)和大肠杆菌(典型的革兰氏阴性菌)具有很强的抗菌效果。对所制备的DFT-C/氧化锌水凝胶的抗菌效果进行了测试。金色和E。双光照射下的菌落总数为99.9%。重要的是，水凝胶在12天内释放锌离子，产生持续的抗菌效果，并促进成纤维细胞的生长。因此，这种杂化水凝胶在重建细菌感染的组织，特别是暴露的伤口方面显示出巨大的潜力。
One of the most difficult challenges in the biomedical field is bacterial infection, which causes tremendous harm to human health. In this work, an injectable hydrogel is synthesized through rapid assembly of dopamine (DA) and folic acid (FA) cross‐linked by transition metal ions (TMIs, i.e., Zn2+), which was named as DFT‐hydrogel. Both the two carboxyl groups in the FA molecule and catechol in polydopamine (PDA) easily chelates Zn2+to form metal–ligand coordination, thereby allowing this injectable hydrogel to match the shapes of wounds. In addition, PDA in the hydrogel coated around carbon quantum dot‐decorated ZnO (C/ZnO) nanoparticles (NPs) to rapidly generate reactive oxygen species (ROS) and heat under illumination with 660 and 808 nm light, endows this hybrid hydrogel with great antibacterial efficacy againstStaphylococcus aureus(S. aureus, typical Gram‐positive bacteria) andEscherichia coli(E. coli, typical Gram‐negative bacteria). The antibacterial efficacy of the prepared DFT‐C/ZnO‐hydrogel againstS. aureusandE. coliunder dual‐light irradiation is 99.9%. Importantly, the hydrogels release zinc ions over 12 days, resulting in a sustained antimicrobial effect and promoted fibroblast growth. Thus, this hybrid hydrogel exhibits great potential for the reconstruction of bacteria‐infected tissues, especially exposed wounds.