Spherical Nucleic Acids
Spherical Nucleic Acids
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DOI：
10.1021/ja209351u
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发表时间：
2012-01-25
影响因子：
15
通讯作者：
Mirkin, Chad A.
中科院分区：
文献类型：
--
作者：
Cutler, Joshua I.;Auyeung, Evelyn;Mirkin, Chad A.
提供了球形核酸（SNA）缀合物和其他三维核酸纳米结构的发展的历史前景。该观点详细介绍了制备它们的合成方法，然后讨论了它们的独特性质以及理解它们的理论和实验模型。还介绍了通过其基本特性使技术进步成为可能的重要例子，这些基本特性跨越了化学，分子诊断，基因调控，医学和材料科学等领域。
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them. Important examples of technological advances made possible by their fundamental properties spanning the fields of chemistry, molecular diagnostics, gene regulation, medicine, and materials science are also presented.