Overview of AKR1C3: Inhibitor Achievements and Disease Insights
Overview of AKR1C3: Inhibitor Achievements and Disease Insights
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AKR1C3的概述：抑制剂成就和疾病见解
DOI：
10.1021/acs.jmedchem.9b02138
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发表时间：
2020-10-22
影响因子：
7.3
通讯作者：
Sun, Haopeng
中科院分区：
文献类型：
--
作者：
Liu, Yang;He, Siyu;Sun, Haopeng
Human aldo-keto reductase family 1 member C3 (AKR1C3) is known as a hormone activity regulator and prostaglandin F (PGF) synthase that regulates the occupancy of hormone receptors and cell proliferation. Because of the overexpression in metabolic diseases and various hormone-dependent and -independent carcinomas, as well as the emergence of clinical drug resistance, an increasing number of studies have investigated AKR1C3 inhibitors. Here, we briefly review the physiological and pathological function of AKR1C3 and then summarize the recent development of selective AKR1C3 inhibitors. We propose our viewpoints on the current problems associated with AKR1C3 inhibitors with the aim of providing a reference for future drug discovery and potential therapeutic perspectives on novel, potent, selective AKR1C3 inhibitors.
