Soluble ST2 levels for predicting the presence and severity of metabolic syndrome.
Soluble ST2 levels for predicting the presence and severity of metabolic syndrome.
复制标题
SST2水平用于预测代谢综合征的存在和严重程度。
DOI：
10.1530/ec-20-0645
复制
发表时间：
2021-03
影响因子：
2.9
通讯作者：
Tao R
中科院分区：
文献类型：
--
作者：
Zong X;Fan Q;Zhang H;Yang Q;Xie H;Chen Q;Zhang R;Tao R
探讨可溶性 ST2 (sST2) 与代谢综合征 (MetS) 之间的关系，并确定 sST2 水平是否可以预测 MetS 的存在和严重程度。我们评估了来自上海交通大学附属瑞金医院血管与心脏病科的 550 名连续受试者（58.91 ± 9.69 岁，50% 男性），有或没有 MetS。测量血清 sST2 浓度。根据 sST2 三分位数，参与者被分为三组。使用单变量和多变量逻辑回归模型来评估血清 sST2 浓度与 MetS 存在之间的关联。 MetS 组的血清 sST2 浓度显着高于无 MetS 组（14.80 ± 7.01 vs 11.58 ± 6.41 ng/mL，P < 0.01）。具有更多 MetS 成分的受试者表现出更高水平的 sST2。多变量调整后，sST2 作为连续对数转换变量与 MetS 的发生相关（每 1 SD，比值比 (OR)：1.42，95% CI：1.13–1.80，P < 0.01）。亚组分析表明，无论性别和年龄如何，患有 MetS 的个体的 sST2 水平均显着高于未患有 MetS 的个体。高血清 sST2 水平与 MetS 的存在和严重程度显着且独立相关。因此，sST2 水平可能是 MetS 的新生物标志物和临床预测因子。
To explore the relationship between soluble ST2 (sST2) and metabolic syndrome (MetS) and determine whether sST2 levels can predict the presence and severity of MetS. We evaluated 550 consecutive subjects (58.91 ± 9.69 years, 50% male) with or without MetS from the Department of Vascular & Cardiology, Shanghai Jiao Tong University-Affiliated Ruijin Hospital. Serum sST2 concentrations were measured. The participants were divided into three groups according to the sST2 tertiles. Univariate and multivariable logistic regression models were used to evaluate the association between serum sST2 concentrations and the presence of MetS. Serum sST2 concentrations were significantly higher in the MetS group than in those in the no MetS group (14.80 ± 7.01 vs 11.58 ± 6.41 ng/mL, P < 0.01). Subjects with more MetS components showed higher levels of sST2. sST2 was associated with the occurrence of MetS after multivariable adjustment as a continuous log-transformed variable (per 1 SD, odds ratio (OR): 1.42, 95% CI: 1.13–1.80, P < 0.01). Subgroup analysis showed that individuals with MetS have significantly higher levels of sST2 than those without MetS regardless of sex and age. High serum sST2 levels were significantly and independently associated with the presence and severity of MetS. Thus, sST2 levels may be a novel biomarker and clinical predictor of MetS.