STOFFWECHSELPRODUKTE VON ACTINOMYCETEN .35. UBER DIE KONSTITUTION DER MAKROTETROLIDE MONACTIN, DINACTIN UND TRINACTIN
STOFFWECHSELPRODUKTE VON ACTINOMYCETEN .35. UBER DIE KONSTITUTION DER MAKROTETROLIDE MONACTIN, DINACTIN UND TRINACTIN
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DOI：
10.1002/hlca.19620450227
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发表时间：
1962-01-01
影响因子：
1.8
通讯作者：
GERLACH, H
中科院分区：
文献类型：
--
作者：
BECK, J;VOSER, W;GERLACH, H
从链霉菌代谢产物nonactin C40 H64 O 12 2）的母液中分离出Monactin C41 H66 O 12、dinactin C42 H88 O 12和trinactin C43 H70 O 12。这些化合物是光学活性的九乳酸和高单乳酸的大环四内酯（“大环四内酯”）I。由光谱数据和降解实验确定的高单乳酸C11 H20 O 4的结构III（R = CH 3，R“= H）与已知的九乳酸C10 H1 O 4 2）的结构III（R= R”-=H）有密切关系。Monactin由2（-）-壬酸、1（+）-壬酸和1（+）-高壬酸组成; dinactin由2（-）-壬酸和2（+）-高壬酸组成; trinactin由1（-）-壬酸、1（-）-高壬酸和2（+）-高壬酸组成。
Monactin C41H66O12, dinactin C42H88O12 and trinactin C43H70O12 have been isolated from the mother liquors of the Streptomyces metabolite nonactin C40H64O12 2). These compounds are macrocyclic tetralactones ("macrotetrolides") I of optically active nonactic and homononactic acids. The structure III (R = CH3, R'' = H) determined for homononactic acid C11H20O4 from spectral data and degradation experiments, shows a close relationship to the structure III (R= R'' -=H) of the known nonactic acid C10H1O 4 2). Monactin is built up from 2(-)-nonactic acids, 1 (+)-nonactic acid and 1 (+)-honmnonor actic acid; dinactin from 2(-)-nonactin acids and 2 (+)-homononactic acids trinactin from 1 (-)-nonaetic acid, l(-)-homononactic acid and 2 (+)-homononactic acids.