Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis.
Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis.
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DOI：
10.2147/idr.s144446
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发表时间：
2017
影响因子：
3.9
通讯作者：
Al-Hajoj S
中科院分区：
文献类型：
--
作者：
Al-Saeedi M;Al-Hajoj S
尽管抗生素可以有效地保护人类免受结核分枝杆菌等许多致命病原体的侵害，但没有什么可以阻止耐药菌株的出现。几种机制促进M.结核病包括补偿性进化，上位性，克隆干扰，细胞壁完整性，外排泵和靶标模拟。在这项研究中，我们提出了与这些机制相关的最新研究结果，这可以发现新的药物靶点，并随后开发用于治疗耐药M的新药。结核
Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant strains. Several mechanisms facilitate drug resistance in M. tuberculosis including compensatory evolution, epistasis, clonal interference, cell wall integrity, efflux pumps, and target mimicry. In this study, we present recent findings relevant to these mechanisms, which can enable the discovery of new drug targets and subsequent development of novel drugs for treatment of drug-resistant M. tuberculosis.