Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
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DOI：
10.1111/j.1349-7006.2003.tb01494.x
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发表时间：
2003-07-01
期刊：
影响因子：
5.7
通讯作者：
Ochiai, T
中科院分区：
文献类型：
--
作者：
Shimada, H;Nabeya, Y;Ochiai, T
高术前血清中期因子浓度与食管癌患者的生存率相关，甚至在根治性手术后，因此可能具有预后价值。中期因子（MK）是一种肝素结合生长因子，在许多癌组织中表达，并且血清MK（S-MK）浓度在各种肿瘤患者中升高。本研究的目的是评价S-MK在食管鳞状细胞癌（SCC）患者中的临床意义。采用酶联免疫吸附法检测135例健康对照者、16例食管良性疾病患者和93例原发性食管鳞癌患者术前血清S-MK水平。检测血清癌胚抗原（CEA）、SCC抗原（SCC-Ag）和细胞角蛋白19片段（CYFRA 21 -1）浓度。所有食管鳞癌患者均行根治性食管切除术。采用免疫组化法检测14例新鲜肿瘤标本中MK的表达。为了确定S-MK是否具有作为预后因素的价值，作者使用考克斯比例风险模型进行了生存分析。食管鳞癌患者的S-MK值显著高于健康对照组（417 +/- 342 pg/ml vs. 154 +/- 76 pg/ml，P
High preoperative serum midkine concentration is associated with poor survival in patients with esophageal cancer, even after radical surgery, and thus may have prognostic value. Midkine (MK), a heparin-binding growth factor, is expressed in numerous cancer tissues, and serum MK (S-MK) concentrations are increased in patients with various neoplasms. The aim of this study is to evaluate the clinical significance of S-MK in patients with esophageal squamous cell cancer (SCC). S-MK was measured by enzyme-linked immunosorbent assay in 135 healthy controls, 16 patients with benign esophageal disease, and 93 patients with primary esophageal SCC before surgery. The serum concentrations of carcinoembryonic antigen (CEA), SCC antigen (SCC-Ag), and cytokeratin 19 fragment (CYFRA21-1) were also evaluated. All patients with esophageal SCC underwent radical esophagectomy. Tumor MK expression was assessed by immunohistochemistry in 14 fresh tumor specimens. To determine whether S-MK is of value as a prognostic factor, the authors conducted a survival analysis using Cox's proportional hazards model. S-MK values in patients with esophageal SCC were significantly higher than those in healthy controls (417 +/- 342 pg/ml vs. 154 +/- 76 pg/ml, P