Therapeutic Exosomes in Prognosis and Developments of Coronary Artery Disease.
Therapeutic Exosomes in Prognosis and Developments of Coronary Artery Disease.
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治疗性外泌体在冠状动脉疾病的预后和发展中的作用。
DOI：
10.3389/fcvm.2021.691548
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发表时间：
2021
影响因子：
3.6
通讯作者：
Chen SL
中科院分区：
文献类型：
--
作者：
Chen AQ;Gao XF;Wang ZM;Wang F;Luo S;Gu Y;Zhang JJ;Chen SL
Exosomes直径30~150 nm，可从几乎所有类型的细胞中释放，含有RNA、蛋白质、脂质等多种有效成分，近年来已被证实在心血管疾病尤其是冠心病的发病机制、诊断、治疗和预后等方面发挥重要作用。此外，还表明来源于不同细胞类型的外泌体具有基于细胞刺激和微环境的各种生物学功能。然而，治疗性外泌体目前距离临床转化还很遥远，尽管它充满了希望。本文综述了近年来有关治疗性exosomes在动脉粥样硬化、心肌梗死和支架内再狭窄中的研究进展，以期为冠心病的治疗提供新的思路，促进治疗性exosomes的临床应用。
Exosomes, with an diameter of 30~150 nm, could be released from almost all types of cells, which contain diverse effective constituent, such as RNAs, proteins, lipids, and so on. In recent years, exosomes have been verified to play an important role in mechanism, diagnosis, treatment, and prognosis of cardiovascular disease, especially coronary artery disease (CAD). Moreover, it has also been shown that exosomes derived from different cell types have various biological functions based on the cell stimulation and microenvironment. However, therapeutic exosomes are currently far away from clinical translation, despite it is full of hope. In this review, we summarize an update of the recent studies and systematic knowledge of therapeutic exosomes in atherosclerosis, myocardial infarction, and in-stent restenosis, which might provide a novel insight into the treatment of CAD and promote the potential clinical application of therapeutic exosomes.
影响因子：
2.1
作者：
Gao XF;Lu S;Ge Z;Zuo GF;Wang ZM;Wang F;Kong XQ;Chai DY;Chen SL;Zhang JJ
通讯作者：
Zhang JJ