Vasodilation Mediated by Inward Rectifier K+ Channels in Cerebral Microvessels of Hypertensive and Normotensive Rats
Vasodilation Mediated by Inward Rectifier K+ Channels in Cerebral Microvessels of Hypertensive and Normotensive Rats
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高血压和正常血压大鼠脑微血管内向整流 K 通道介导的血管舒张作用
DOI：
10.1213/01.ane.0000194303.00844.5e
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发表时间：
2006
影响因子：
5.7
通讯作者：
Y. Hatano
中科院分区：
文献类型：
--
作者：
Katsutoshi Nakahata;H. Kinoshita;Y. Tokinaga;Y. Ishida;Y. Kimoto;M. Dojo;K. Mizumoto;K. Ogawa;Y. Hatano
虽然内向整流钾离子通道有助于脑循环的调节，但在慢性高血压中尚未证实由这些通道介导的脑微血管扩张。本研究旨在探讨高血压和正常血压大鼠脑实质小动脉细胞外K+水平升高所产生的血管舒张中内向整流性K+通道的作用。在前列腺素F2（5 × 10−7 M）收缩期间，使用计算机辅助显微镜评估脑切片内的小动脉。氯化钾（KCl）诱导血压正常（5-10 mM）和高血压（5-15 mM）大鼠脑小动脉血管舒张，而内向整流钾通道拮抗剂氯化钡（BaCl 2; 10−5 M）完全消除了两种品系大鼠的血管舒张。在高血压大鼠的小动脉中，与正常血压大鼠相比，KCl的血管舒张反应增强。相比之下，硝普钠（3 × 10−8至3 × 10−6 M）在这两种菌株中诱导的血管舒张反应相似。这些结果表明，在大脑皮质实质微血管中，内向整流性K+通道在细胞外K+产生的血管舒张中发挥着至关重要的作用，并且在慢性高血压中，通过这些通道的脑小动脉扩张增强。
Although inward rectifier K+ channels contribute to the regulation of cerebral circulation, dilation of cerebral microvasculature mediated by these channels has not been demonstrated in chronic hypertension. We designed the present study to examine the roles of inward rectifier K+ channels in the vasodilation produced by increased levels of extracellular K+ in cerebral parenchymal arterioles from hypertensive and normotensive rats. During constriction to prostaglandin F2&agr; (5 × 10−7 M), the arterioles within brain slices were evaluated using computer-assisted microscopy. Potassium chloride (KCl) induced vasodilation in cerebral arterioles from normotensive (5–10 mM) and hypertensive (5–15 mM) rats, whereas an inward rectifier K+ channel antagonist barium chloride (BaCl2; 10−5 M) completely abolished the vasodilation in both strains. In arterioles of hypertensive rats, vasodilator responses to KCl were augmented compared with those in normotensive rats. In contrast, the vasodilator responses induced by sodium nitroprusside (3 × 10−8 to 3 × 10−6 M) in these two strains were similar. These results suggest that in cerebral cortex parenchymal microvessels, inward rectifier K+ channels play a crucial role in vasodilation produced by extracellular K+ and that the dilation of cerebral arterioles via these channels is augmented in chronic hypertension.
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DOI：
10.1152/ajpheart.1993.264.6.h1774
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1152/ajpheart.2000.278.3.h878
发表时间：
2000
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Nguyen,TS;Winn,HR;Janigro,D
通讯作者：
Janigro,D
影响因子：
56.9
作者：
PAULSON, OB;NEWMAN, EA
通讯作者：
NEWMAN, EA
影响因子：
20.1
作者：
J. Zaritsky;D. Eckman;G. Wellman;M. Nelson;T. Schwarz
通讯作者：
J. Zaritsky;D. Eckman;G. Wellman;M. Nelson;T. Schwarz
影响因子：
--
作者：
QUAYLE, JM;MCCARRON, JG;NELSON, MT
通讯作者：
NELSON, MT