Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis
Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis
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DOI：
10.1016/j.jneuroim.2012.04.010
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发表时间：
2012-08-15
影响因子：
3.3
通讯作者：
Beineke, Andreas
中科院分区：
文献类型：
--
作者：
Herder, Vanessa;Gerhauser, Ingo;Beineke, Andreas
保护性免疫降低导致泰勒氏小鼠脑脊髓炎的病毒持久性和脱髓鞘。本研究的目的是比较在泰勒氏病毒诱导的急性脊髓灰质炎过程中，敏感的SJL小鼠和耐药的C57BL/6小鼠脑内白细胞的表型和细胞因子的表达。与C57/BL6小鼠相比，SJL小鼠表现出与延迟病毒清除相关的Foxp3(+)调节性T细胞和CD45R(+)B细胞的数量增加，以及大脑中IL-10mRNA转录的增加。结果证实了一个假设，即在感染早期，细胞因子环境的失衡导致具有易感遗传背景的动物的抗病毒免疫无效。(C)2012爱思唯尔B.V.保留所有权利。
Reduced protective immunity leads to viral persistence and demyelination in Theiler's murine encephalomyelitis. The aim of the present study was to compare the phenotype of brain-infiltrating leukocytes and cytokine expression in susceptible SJL and resistant C57BL/6 mice during Theilervirus-induced acute polioencephalitis. In contrast to C57/BL6 mice, SJL mice show an increased number of Foxp3(+) regulatory T cells and CD45R(+) B cells associated with delayed viral elimination and elevated IL-10 mRNA transcripts in the brain. Results substantiate the hypothesis that an imbalanced cytokine milieu during the early infection phase contributes to ineffective antiviral immunity in animals with a susceptible genetic background. (C) 2012 Elsevier B.V. All rights reserved.