A new drug delivery system using plasma-irradiated pharmaceutical aids. VI. Controlled release of theophylline from plasma-irradiated double-compressed tablet composed of water-soluble polymers as a wall material.
A new drug delivery system using plasma-irradiated pharmaceutical aids. VI. Controlled release of theophylline from plasma-irradiated double-compressed tablet composed of water-soluble polymers as a wall material.
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一种使用等离子体辐照药物辅助剂的新型药物输送系统。
DOI：
10.1248/cpb.44.192
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发表时间：
1996
影响因子：
1.7
通讯作者：
S. Kondo
中科院分区：
文献类型：
--
作者：
M. Kuzuya;M. Ishikawa;T. Noguchi;J. Niwa;S. Kondo
以水溶性高分子聚甲基丙烯酸（PMAA）或聚丙烯酰胺（PAAm）为壁材的茶碱双层压片，经氩等离子体辐照后，由于外层水溶性高分子溶解度降低，可抑制药物的快速释放，使其转变为缓慢释放。本报告首次尝试通过控制聚合物的溶解度来控制药物的释放，并利用等离子体处理来制造完全可溶的控释型药物递送系统（DDS）。
The rapid drug release from a double-compressed tablet containing theophylline with the water-soluble polymer polymethacrylic acid (PMAA) or polyacrylamide (PAAm) used as a wall material can be suppressed by argon plasma irradiation and changed into the slow release due to a decrease in the solubility of water-soluble polymers used as the outer layer. This report is the first to deal with an attempt to control the release of drugs by controlling polymer solubility, and to fabricate a completely soluble controlled release type of drug delivery system (DDS) making use of plasma processing.