Aδ and C primary afferents convey dorsal root reflexes after intradermal injection of capsaicin in rats
Aδ and C primary afferents convey dorsal root reflexes after intradermal injection of capsaicin in rats
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DOI：
10.1152/jn.2000.84.5.2695
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发表时间：
2000-11-01
影响因子：
2.5
通讯作者：
Willis, WD
中科院分区：
文献类型：
--
作者：
Lin, Q;Zou, XJ;Willis, WD
在麻醉大鼠L4-6节段切断背根细丝的近端记录单个传入纤维的逆行活动，并测试其对皮内注射辣椒素引起的急性皮肤炎的反应。这种逆行活动包括通过将von Frey毛发应用于足部皮肤而引起的低频自发放电和背根反射(DRR)放电。小的有髓(A三角)和无髓(C)传入纤维以及大的有髓(Aβ)纤维均可记录到DRRs。将辣椒素注射到足底皮肤后，A三角洲和C纤维的DRR活性显著增强，而Aβ纤维的DRR活性没有明显增强，这种增强持续到1h。本研究支持中枢介导的A三角洲和C初级传入纤维的逆行活动参与神经源性炎症的发展，可能是通过在外周释放炎性物质。
Antidromic activity was recorded in anesthetized rats from single afferent fibers in the proximal ends of cut dorsal root filaments at the L4-6 level and tested for responses to acute cutaneous inflammation produced by intradermal injection of capsaicin. This antidromic activity included low-frequency spontaneous firing and dorsal root reflex (DRR) discharges evoked by applying von Frey hairs to the skin of the foot. DRRs could be recorded from both small myelinated (A delta) and unmyelinated (C) afferent fibers, as well as from large myelinated (A beta) fibers. After capsaicin was injected intradermally into the plantar skin of the foot, a significant enhancement of DRR activity was seen in A delta and C fibers but not in A beta fibers, and this increase lasted for similar to1 h. This study supports the hypothesis that centrally mediated antidromic activity in A delta and C primary afferent fibers contributes to the development of neurogenic inflammation, presumably by release of inflammatory substances in the periphery.