Association of Tumor Necrosis Factor-α Gene G-308A Polymorphism with Dilated Cardiomyopathy: A Meta-Analysis
Association of Tumor Necrosis Factor-α Gene G-308A Polymorphism with Dilated Cardiomyopathy: A Meta-Analysis
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DOI：
10.1089/dna.2012.1911
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发表时间：
2013-03-01
影响因子：
3.1
通讯作者：
Wu, Xiushan
中科院分区：
文献类型：
--
作者：
Luo, Rong;Li, Xiaoping;Wu, Xiushan
关于肿瘤坏死因子-α（TNF-α）G-308 A基因多态性与扩张型心肌病（DCM）风险之间的关联的已发表数据尚不确定。为了阐明TNF-α G-308 A基因多态性与DCM的相关性，进行了病例对照研究的荟萃分析。检索了一些数据库，如PubMed和Embase，以识别相关研究。检索词包括扩张型心肌病、肿瘤坏死因子-α或TNF-α或TNF-α或肿瘤坏死因子α以及多态性或突变。8项病例对照研究包括1487例DCM病例和1734例正常对照，纳入荟萃分析，以评估TNF-α G-308 A基因多态性与DCM风险之间的关系。采用显性遗传模型，比较GA/AA基因型与GG基因型。比值比为1.42（95%可信区间：1.05，1.93，P = 0.02），DCM患者TNF-α-308 GA/AA基因型的出现频率高于对照组。TNF-α G-308 A核苷酸转换可能与DCM的风险有关。
Published data on the association between tumor necrosis factor-alpha (TNF-alpha) G-308A gene polymorphism and dilated cardiomyopathy (DCM) risk are inconclusive. To clarify the association of TNF-alpha G-308A gene poly-morphism and DCM, a meta-analysis of case-control studies was performed. Some databases, such as PubMed and Embase, were searched to indentify related studies. Search terms included dilated cardiomyopathy, tumor necrosis factor-alpha or TNF-alpha or TNF alpha or tumor necrosis factor alpha, and polymorphism or mutation. Eight case-control studies involving 1487 DCM cases and 1734 normal controls were included in the meta-analysis to assess the purported association between the TNF-alpha G-308A gene polymorphism and the risk of DCM. A dominant genetic model was used and the comparison of GA/AA genotype versus GG genotype was performed in the present meta-analysis. The odds ratio was 1.42 (95% confidence interval: 1.05, 1.93, P = 0.02), manifesting frequency of the TNF-alpha-308 GA/AA genotype was higher in DCM patients than the control group. TNF-alpha G-308A nucleotide transition might be associated with the risk of DCM.