Gene Regulation by Histone Arginine Modifications
Gene Regulation by Histone Arginine Modifications
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组蛋白精氨酸修饰的基因调控
DOI：
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发表时间：
2008
影响因子：
0.3
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中科院分区：
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蛋白质精氨酸甲基转移酶（PRMT）对组蛋白的甲基化在基因调控中发挥着重要作用。 PRMT1 和 PRMT4 催化的甲基精氨酸参与转录激活，而 PRMT5 和 PRMT6 催化的甲基精氨酸与转录抑制相关。组蛋白精氨酸甲基化在体内可动态调控，甲基精氨酸通过“精氨酸去甲基酶”去甲基化。本文总结了组蛋白精氨酸甲基化研究的最新进展。
Methylation of histone by protein arginine methyltransferases (PRMTs) plays an important role in gene regulation. PRMT1- and PRMT4-catalyzed methyl-arginine is involved in transcription activation, while PRMT5- and PRMT6-catalyzed methyl-arginine is associated with transcription repression. Histone arginine methylation can be dynamically regulated in vivo, and methyl-arginine is demethylated by "arginine demethylase". Here, the most recent progresses in the methylation studies of histone arginine were summarized.