Visual recognition in monkeys following rhinal cortical ablations combined with either amygdalectomy or hippocampectomy
Visual recognition in monkeys following rhinal cortical ablations combined with either amygdalectomy or hippocampectomy
复制标题
鼻皮质消融联合杏仁核切除术或海马切除术后猴子的视觉识别
作者：
E. Murray;M. Mishkin
我们评估了食蟹猴在视觉识别任务上的表现，这些食蟹猴切除了鼻皮层（即鼻皮层、鼻前皮层和鼻周围皮层），并结合了杏仁核切除术或海马切除术，以及未手术的对照组。海马体和鼻皮层的切除导致轻度的识别缺陷，而杏仁核复合体和鼻皮层的切除导致严重的识别缺陷。将结果与早期研究（Mishkin, 1978）的结果进行比较表明，在海马切除术中加入鼻皮质切除术对识别的额外损害很小，如果有的话。相比之下，在杏仁核切除术的基础上再加一个鼻皮质切除会产生深远的影响；事实上，杏仁核+鼻腔切除的猴子的识别障碍至少与杏仁核+海马联合切除的猴子一样严重。综上所述，这些结果支持这样的结论：杏仁核和海马系统的联合损伤是产生严重识别缺陷的必要条件。此外，他们认为，切除鼻皮质的效果相当于切除整个海马结构，可能是因为鼻皮质消融切断了海马体与其新皮质输入的连接。
Performance on a visual recognition task was assessed in cynomolgus monkeys with ablations of rhinal (i.e., ento-, pro-, and perirhinal) cortex in combination with either amygdalectomy or hippocampectomy, as well as in unoperated controls. Removal of the hippocampal formation plus rhinal cortex resulted in a mild recognition deficit, whereas removal of the amygdaloid complex plus rhinal cortex resulted in a severe deficit. Comparison of the results with those of an earlier study (Mishkin, 1978) indicates that adding a rhinal cortical removal to hippocampectomy yields little, if any, additional impairment in recognition. By contrast, adding a rhinal cortical removal to an amygdalectomy has a profound effect; indeed, the recognition impairment in monkeys with amygdaloid plus rhinal removals was at least as severe as that seen in monkeys with combined amygdaloid and hippocampal removals. Taken together, these results support the conclusion that combined damage to the amygdaloid and hippocampal systems is necessary to produce a severe recognition deficit. In addition, they suggest that the effect of ablating the rhinal cortex is equivalent to that of removing the entire hippocampal formation, presumably because the rhinal cortical ablation disconnects the hippocampus from its neocortical input.