Associations between obesity and cognitive impairment in the Chinese elderly: an observational study
Associations between obesity and cognitive impairment in the Chinese elderly: an observational study
复制标题
DOI：
10.2147/cia.s192050
复制
发表时间：
2019-01-01
影响因子：
3.6
通讯作者：
Lu, Yang
中科院分区：
文献类型：
--
作者：
Hou, Qingtao;Guan, Yang;Lu, Yang
目的：本研究的目的是探讨中国老年人肥胖与认知功能障碍的关系。患者和方法：2013年3月至2017年5月在重庆医科大学附属第一医院老年科招募的60岁及以上患者。采用简易精神状态检查量表评定认知功能。采用体重指数（BMI）和腰臀比对肥胖进行分类。学生的t检验，曼-惠特尼U检验，或卡方检验被用来比较数据之间的参与者与正常的认知和参与者与认知障碍的适当。结果：共纳入1,100例患者，其中男性568例，女性532例，年龄60-98岁（中位年龄79岁）。在调整年龄、性别、吸烟、饮酒、教育水平、高胆固醇血症、高血压和糖尿病等因素后，超重与认知功能障碍风险降低显著相关（OR=0.458，95%CI =0.298-0.703，P
Purpose: The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly.Patients and methods: Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May 2017. Mini-Mental State Examination scale was used to assess the cognitive function. Body mass index (BMI) and waist-hip ratio were used to classify obesity. Student's t-test, Mann-Whitney U-test, or chi-squared test was used to compare the data between participants with normal cognition and participants with cognitive impairment as appropriate. Univariate logistic regression models and multivariate logistic regression models were performed to explore the relationship between BMI or abdominal obesity and cognitive impairment.Results: A total of 1,100 patients including 568 men and 532 women aged 60-98 years (median age 79 years) were enrolled. After adjusting for age, gender, smoking, drinking, education level, hypercholesterolemia, hypertension, and diabetes, overweight was significantly associated with a decreased risk of cognitive impairment (OR=0.458, 95% CI=0.298-0.703, P